| Literature DB >> 2868257 |
L S Young, D Clark, J W Sixbey, A B Rickinson.
Abstract
The apparently strict tropism of Epstein-Barr virus (EBV) for B lymphocytes has been attributed to the existence of a B-lineage-specific surface molecule, the C3d receptor, which also functions as a receptor for EBV. Two monoclonal antibodies against different determinants on the EBV/C3d receptor of B cells were shown to react with pharyngeal epithelia in a cell differentiation-dependent manner. These findings, which raise the possibility of direct virus entry into a naturally exposed epithelium, strengthen the evidence in favour of an epithelial reservoir of EBV infection in vivo and identify a means whereby the virus/epithelium interactions leading to nasopharyngeal carcinoma might be initiated.Entities:
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Year: 1986 PMID： 2868257 DOI： 10.1016/s0140-6736(86)90776-2
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321