| Literature DB >> 28682465 |
Yanyan Hu1,2, Chongwei Chi2, Shunhao Wang3,4,5, Lingxiong Wang6, Ping Liang1, Fangyi Liu1, Wenting Shang2, Weiwei Wang3, Fengrong Zhang3, Shanshan Li3, Heyun Shen3, Xiaoling Yu1, Huiyu Liu3, Jie Tian2,5.
Abstract
Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (125 I) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.Entities:
Keywords: active targeting; clinical intervention; gold nanoshells; interventional photothermal therapy; pancreatic cancer
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Year: 2017 PMID： 28682465 DOI： 10.1002/adma.201700448
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849