Vanja Mandic-Maravic1, Marija Pljesa-Ercegovac2,3, Marija Mitkovic-Voncina1,3, Ana Savic-Radojevic2,3, Dusica Lecic-Tosevski1,3,4, Tatjana Simic2,3, Milica Pejovic-Milovancevic5,6. 1. Institute of Mental Health, Palmotićeva 37, 11000 Belgrade, Serbia. 2. Institute for Medical and Clinical Biochemistry, Belgrade, Serbia. 3. Faculty of Medicine, University of Belgrade, Belgrade, Serbia. 4. Serbian Academy of Sciences and Arts, Belgrade, Serbia. 5. Institute of Mental Health, Palmotićeva 37, 11000 Belgrade, Serbia. milica.pejovic@imh.org.rs. 6. Faculty of Medicine, University of Belgrade, Belgrade, Serbia. milica.pejovic@imh.org.rs.
Abstract
PURPOSE OF REVIEW: This review aims to provide a brief description of the complex etiology of autism spectrum disorders (ASD), with special emphasis on the recent findings of impaired redox control in ASD, and to suggest a possible model of oxidative stress-specific gene-environment interaction in this group of disorders. RECENT FINDINGS: Recent findings point out to the significance of environmental, prenatal, and perinatal factors in ASD but, at the same time, are in favor of the potentially significant oxidative stress-specific gene-environment interaction in ASD. Available evidence suggests an association between both the identified environmental factors and genetic susceptibility related to the increased risk of ASD and the oxidative stress pathway. There might be a potentially significant specific gene-environment interaction in ASD, which is associated with oxidative stress. Revealing novel susceptibility genes (including those encoding for antioxidant enzymes), or environmental factors that might increase susceptibility to ASD in carriers of a specific genotype, might enable the stratification of individuals more prone to developing ASD and, eventually, the possibility of applying preventive therapeutic actions.
PURPOSE OF REVIEW: This review aims to provide a brief description of the complex etiology of autism spectrum disorders (ASD), with special emphasis on the recent findings of impaired redox control in ASD, and to suggest a possible model of oxidative stress-specific gene-environment interaction in this group of disorders. RECENT FINDINGS: Recent findings point out to the significance of environmental, prenatal, and perinatal factors in ASD but, at the same time, are in favor of the potentially significant oxidative stress-specific gene-environment interaction in ASD. Available evidence suggests an association between both the identified environmental factors and genetic susceptibility related to the increased risk of ASD and the oxidative stress pathway. There might be a potentially significant specific gene-environment interaction in ASD, which is associated with oxidative stress. Revealing novel susceptibility genes (including those encoding for antioxidant enzymes), or environmental factors that might increase susceptibility to ASD in carriers of a specific genotype, might enable the stratification of individuals more prone to developing ASD and, eventually, the possibility of applying preventive therapeutic actions.
Entities:
Keywords:
Autism spectrum disorders; Gene-environment interaction; Oxidative stress; Redox control
Authors: Yeni Kim; Krishna C Vadodaria; Zsolt Lenkei; Tadafumi Kato; Fred H Gage; Maria C Marchetto; Renata Santos Journal: Antioxid Redox Signal Date: 2019-02-01 Impact factor: 8.401
Authors: Samuel Tanner; Sarah Thomson; Katherine Drummond; Martin O'Hely; Christos Symeonides; Toby Mansell; Richard Saffery; Peter D Sly; Fiona Collier; David Burgner; Eva J Sugeng; Terence Dwyer; Peter Vuillermin; Anne-Louise Ponsonby Journal: Antioxidants (Basel) Date: 2022-03-29
Authors: Vanja Mandic-Maravic; Marija Mitkovic-Voncina; Marija Pljesa-Ercegovac; Ana Savic-Radojevic; Miroslav Djordjevic; Tatjana Pekmezovic; Roberto Grujicic; Marko Ercegovac; Tatjana Simic; Dusica Lecic-Tosevski; Milica Pejovic-Milovancevic Journal: Front Psychiatry Date: 2019-09-25 Impact factor: 4.157