Literature DB >> 28681233

Effective DABCO-catalyzed synthesis of new tetrazolo[1,5-a]pyrimidine analogs.

Ramin Ghorbani-Vaghei1, Azadeh Shahriari2, Jafar Mahmoodi2, Yaser Maghbooli2.   

Abstract

In this study, an efficient multicomponent one-pot route is described for the DABCO-catalyzed synthesis of tetrazolo[1,5-a]pyrimidines. This synthesis strategy is based on the reaction of malononitrile and aldehydes with 5-aminotetrazole monohydrate using 1,4-diazabicyclo[2.2.2]octane (DABCO) in i-PrOH under reflux conditions. This protocol is a simple, green, and low-cost technique to prepare new compounds with potential medicinal properties.

Entities:  

Keywords:  5-aminotetrazole monohydrate; DABCO; MCRs; Multicomponent; One-pot; Tetrazolo[1, 5-a]pyrimidines

Mesh：

Substances：

Year:  2017        PMID： 28681233     DOI： 10.1007/s11030-017-9760-9

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  5 in total

1.  Synthesis of some heterocycles of pharmaceutical interest.

Authors:  M A Metwally; M S el-Hussiny; F Z el-Ablak; A M Khalil
Journal:  Pharmazie       Date:  1989-04       Impact factor: 1.267

2.  Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a]pyrimidine derivatives.

Authors:  Ahmed M Hussein; Osama M Ahmed
Journal:  Bioorg Med Chem       Date:  2010-02-20       Impact factor: 3.641

3.  Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.

Authors:  Wenquan Yu; Cally Goddard; Elizabeth Clearfield; Courtney Mills; Tong Xiao; Haitao Guo; John D Morrey; Neil E Motter; Kang Zhao; Timothy M Block; Andrea Cuconati; Xiaodong Xu
Journal:  J Med Chem       Date:  2011-08-02       Impact factor: 7.446

4.  A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.

Authors:  Anne Marie Dougherty; Haitao Guo; Gael Westby; Yuanjie Liu; Ender Simsek; Ju-Tao Guo; Anand Mehta; Pamela Norton; Baohua Gu; Timothy Block; Andrea Cuconati
Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

5.  Iodine catalyzed one-pot multicomponent synthesis of a library of compounds containing tetrazolo[1,5-a]pyrimidine core.

Authors:  Li-Yan Zeng; Chun Cai
Journal:  J Comb Chem       Date:  2010 Jan-Feb
  5 in total

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