Literature DB >> 2868094

Drug delivery to the proximal colon.

J G Hardy, C G Wilson, E Wood.   

Abstract

The transits of a capsule and a multiparticulate pellet system have been monitored through the gastrointestinal tract in six healthy volunteers. Both preparations moved together through the stomach and small intestine, reaching the colon, on average, 4 h after dosing. Within the colon the pellets dispersed and moved at a slower rate than the capsule. There was considerable intersubject variability in the large bowel transit times. The findings are discussed in terms of drug delivery to the colon.

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Year:  1985        PMID： 2868094     DOI： 10.1111/j.2042-7158.1985.tb04992.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  26 in total

1.  Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system.

Authors:  J M Hebden; C G Wilson; R C Spiller; P J Gilchrist; E Blackshaw; M E Frier; A C Perkins
Journal:  Pharm Res       Date:  1999-07       Impact factor: 4.200

2.  Measurement of segmental transit through the gut in man. A novel approach by the biomagnetic method.

Authors:  M Basile; M Neri; A Carriero; S Casciardi; S Comani; C Del Gratta; L Di Donato; S Di Luzio; M A Macri; A Pasquarelli
Journal:  Dig Dis Sci       Date:  1992-10       Impact factor: 3.199

Review 3.  Gamma scintigraphy in the evaluation of pharmaceutical dosage forms.

Authors:  S S Davis; J G Hardy; S P Newman; I R Wilding
Journal:  Eur J Nucl Med       Date:  1992

Review 4.  Nuclear medicine techniques in the evaluation of pharmaceutical formulations.

Authors:  A C Perkins; M Frier
Journal:  Pharm World Sci       Date:  1996-06

5.  Biopharmaceutical considerations and characterizations in development of colon targeted dosage forms for inflammatory bowel disease.

Authors:  Rajkumar Malayandi; Phani Krishna Kondamudi; P K Ruby; Deepika Aggarwal
Journal:  Drug Deliv Transl Res       Date:  2014-04       Impact factor: 4.617

6.  Relationship between the rate of appearance of oxprenolol in the systemic circulation and the location of an oxprenolol Oros 16/260 drug delivery system within the gastrointestinal tract as determined by scintigraphy.

Authors:  S S Davis; N Washington; G D Parr; A H Short; V A John; P Lloyd; S M Walker
Journal:  Br J Clin Pharmacol       Date:  1988-10       Impact factor: 4.335

Review 7.  More movement with evaluating colonic transit in humans.

Authors:  Adil E Bharucha; Bradley Anderson; Michel Bouchoucha
Journal:  Neurogastroenterol Motil       Date:  2019-02       Impact factor: 3.598

8.  Dosimetry of swallowed non absorbed 99mTc radiopharmaceuticals in pediatric patients.

Authors:  S Wynchank; M D Mann; R Gonin
Journal:  Eur J Nucl Med       Date:  1990

9.  Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled-release system and as a suspension of 15N-labelled drug to healthy volunteers.

Authors:  I R Wilding; S S Davis; J G Hardy; C S Robertson; V A John; M L Powell; M Leal; P Lloyd; S M Walker
Journal:  Br J Clin Pharmacol       Date:  1991-11       Impact factor: 4.335

Review 10.  The nifedipine gastrointestinal therapeutic system (GITS). Evaluation of pharmaceutical, pharmacokinetic and pharmacological properties.

Authors:  J S Grundy; R T Foster
Journal:  Clin Pharmacokinet       Date:  1996-01       Impact factor: 6.447
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