Abd Elrazek1, Samy Saab2, Mahmoud Foad3, Elsayed A Elgohary4, Mohammad M Sallam4, Abdallah Nawara4, Ali Ismael4, Samar S Morsi5, Altaher Salah6, Mohamed Alboraie7, Akshaya Srikanth Bhagavathula8, Marwa Zayed9, Hossam Elmasry10, Tamer Z Salem11. 1. Department of Hepatology and Gastroenterology, Aswan School of Medicine, Aswan University, Egypt. 2. Department of Medicine and Surgery, David Geffen School of Medicine, University of California Los Angeles (UCLA), USA. 3. Department of Gynecology and Obstetrics, Al Azhar Asuit Faculty of Medicine, Al Azhar UniversityEgypt. 4. Department of Internal Medicine, Zagazig Faculty of Medicine, Zagazig University, Zagazig, Egypt. 5. Department of Microbiology and Immunology, Zagazig Faculty of Medicine, Zagazig University, Egypt. 6. Department of Gynecology and Obstetrics, Al Galaa teaching Hospital, Cairo, Egypt. 7. Department of Internal Medicine, Al Azhar University, Cairo, Egypt. 8. Department of Clinical Pharmacy, University of Gondar College of Medicine and Health Sciences, Gondar, Ethiopia. 9. Department of Gastroenterology and Hepatology, Ahmed Maher Teaching Hospital, Cairo, Egypt. 10. Cardiology and Internal Medicine, Cabinet of Ministers, Cairo, Egypt. 11. Biomedical Sciences, University of Science and Technology at Zewail City, Giza, Egypt.
Abstract
BACKGROUND AND OBJECTIVES: Over the past few decades, cesarean section (CS) rates are steadily increasing in most of the middle- and high-income countries. However, most of the pregnant women (particularly undergoing CS) are not screened for hepatitis C virus (HCV); hence, neonates born to HCV-positive mother could be a source of future HCV infection. In this study, the role of the CS and other surgical interventions in HCV transmission in Egypt, the highest endemic country of HCV-4, was investigated. METHODS: From January to June 2016, a prospective cohort study was conducted among 3,836 pregnant women in both urban and rural areas across Egypt for HCV screening in both mothers and neonates born to HCV-positive mother. All pregnant women were screened during third trimester or just before delivery, neonates born to HCV-positive mothers were evaluated within 24-h postdelivery to record vertical transmission cases. Data mining (DM)-driven computational analysis was used to quantify the findings. RESULTS: Among 3,836 randomized pregnant women, HCV genotype 4 was identified in 80 women (2.08%). Out of 80 HCV-infected women, 18 have experienced surgical intervention (22.5%) and 62 CS (77.5%). HCV vertical transmission was identified in 10 neonates, 10/80 (12.5%). CONCLUSION: Screening women who had experienced surgical intervention or CS during child bearing period and before pregnancy might prevent HCV mother-to-child transmission (MTCT). CS should be ethically justified to decrease global HCV transmission.
BACKGROUND AND OBJECTIVES: Over the past few decades, cesarean section (CS) rates are steadily increasing in most of the middle- and high-income countries. However, most of the pregnant women (particularly undergoing CS) are not screened for hepatitis C virus (HCV); hence, neonates born to HCV-positive mother could be a source of future HCV infection. In this study, the role of the CS and other surgical interventions in HCV transmission in Egypt, the highest endemic country of HCV-4, was investigated. METHODS: From January to June 2016, a prospective cohort study was conducted among 3,836 pregnant women in both urban and rural areas across Egypt for HCV screening in both mothers and neonates born to HCV-positive mother. All pregnant women were screened during third trimester or just before delivery, neonates born to HCV-positive mothers were evaluated within 24-h postdelivery to record vertical transmission cases. Data mining (DM)-driven computational analysis was used to quantify the findings. RESULTS: Among 3,836 randomized pregnant women, HCV genotype 4 was identified in 80 women (2.08%). Out of 80 HCV-infected women, 18 have experienced surgical intervention (22.5%) and 62 CS (77.5%). HCV vertical transmission was identified in 10 neonates, 10/80 (12.5%). CONCLUSION: Screening women who had experienced surgical intervention or CS during child bearing period and before pregnancy might prevent HCV mother-to-child transmission (MTCT). CS should be ethically justified to decrease global HCV transmission.
Entities:
Keywords:
Cesarean Section; data mining; hepatitis C virus; pregnant women; vertical transmission
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