Literature DB >> 2868020

Capillary gas chromatographic-mass spectrometric determination of buspirone in plasma.

R E Gammans, E H Kerns, W W Bullen.   

Abstract

Methods for determining buspirone plus a deuterated analogue and for buspirone alone in plasma samples are described. Analytes are prepared from plasma by liquid extraction into n-butyl chloride and subsequent back-extraction clean-up steps. Instrumental analysis involves selected-ion monitoring gas chromatography-mass spectrometry with fused-silica capillary chromatography. Quantification is in the range 0.05-10 ng/ml with acceptable accuracy and precision.

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Year:  1985        PMID: 2868020     DOI: 10.1016/0378-4347(85)80166-3

Source DB:  PubMed          Journal:  J Chromatogr


  2 in total

Review 1.  Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.

Authors:  I Mahmood; C Sahajwalla
Journal:  Clin Pharmacokinet       Date:  1999-04       Impact factor: 6.447

Review 2.  Buspirone. A preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic.

Authors:  K L Goa; A Ward
Journal:  Drugs       Date:  1986-08       Impact factor: 9.546

  2 in total

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