Song Fan1, Jiang-Long Zhong2, Wei-Xiong Chen2, Wei-Liang Chen3, Qun-Xing Li2, You-Yuan Wang2, Zhao-Yu Lin2, Han-Qing Zhang2, Da-Ming Zhang2, Xin Yu2, Fa-Ya Liang4, Xiao-Ming Huang4, Eduardo Dias-Ribeiro5, Yong Liu6, Xiang-Hua Lin6, Bin Zhou2, Qi-Xiang Liang2, Celso Koogi Sonoda5, Jin-Song Li7. 1. Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital, Guangzhou 510120, China. 2. Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China. 3. Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China. Electronic address: drchen@vip.163.com. 4. Department of Otorhinolaryngology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China. 5. Department of Oral and Maxillofacial Surgery, Dental School of Araçatuba, Universidade Estadual Paulista (UNESP), Araçatuba, São Paulo, Brazil. 6. Morphologic & Biochemical Lab of Pediatric Hematology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China. 7. Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital, Guangzhou 510120, China. Electronic address: lijs2015@yeah.net.
Abstract
BACKGROUND:Endoscopically assisted selective neck dissection (SND) has recently been applied in clinical N0 cases of oral squamous cell carcinoma (OSCC). However, nothing is known of the immune response after surgery. METHODS: A total of 60 patients with cT1-2N0 OSCC randomly underwentendoscopically assisted SND and open operations. The serum levels of IL-6, IL-8, IL-10, IL-1b, TNF-a, CRP, cortisol, ACTH, and growth hormone were analyzed before the start of the surgery (T0) and at 2 (T1), 6 (T2), 24 (T3), and 72 h (T4) after surgery. RESULTS: A total of 31 patients were randomized for endoscopic SND, whereas 29 underwent open procedures. The release of IL-6, IL-10 and CRP was significantly lower in the endoscopic group than in the open surgery group (p < 0.05), and cortisol levels were also lower in the endoscopic group (p < 0.05). CONCLUSIONS:Endoscopic SND could effectively provide lower inflammatory responses and surgical stress, reducing peri-operative trauma and accelerating recovery.
RCT Entities:
BACKGROUND: Endoscopically assisted selective neck dissection (SND) has recently been applied in clinical N0 cases of oral squamous cell carcinoma (OSCC). However, nothing is known of the immune response after surgery. METHODS: A total of 60 patients with cT1-2N0 OSCC randomly underwent endoscopically assisted SND and open operations. The serum levels of IL-6, IL-8, IL-10, IL-1b, TNF-a, CRP, cortisol, ACTH, and growth hormone were analyzed before the start of the surgery (T0) and at 2 (T1), 6 (T2), 24 (T3), and 72 h (T4) after surgery. RESULTS: A total of 31 patients were randomized for endoscopic SND, whereas 29 underwent open procedures. The release of IL-6, IL-10 and CRP was significantly lower in the endoscopic group than in the open surgery group (p < 0.05), and cortisol levels were also lower in the endoscopic group (p < 0.05). CONCLUSIONS: Endoscopic SND could effectively provide lower inflammatory responses and surgical stress, reducing peri-operative trauma and accelerating recovery.
Authors: Vishal M Bulsara; Helen V Worthington; Anne-Marie Glenny; Janet E Clarkson; David I Conway; Michaelina Macluskey Journal: Cochrane Database Syst Rev Date: 2018-12-24
Authors: Jehan Ahmed Sayed; Sayed Kaoud Abd Elshafy; Emad Zareif Kamel; Mohamed Amir Fathy Riad; Amal Ahmed Mahmoud; Ghada Shalaby Khalaf Journal: Korean J Pain Date: 2018-07-02