Literature DB >> 2867935

Amino acid substitutions in mitochondrial ATPase subunit 9 of Saccharomyces cerevisiae leading to oligomycin or venturicidin resistance.

P Nagley, R M Hall, B G Ooi.   

Abstract

A series of isonuclear oligomycin-resistant mutants of Saccharomyces cerevisiae carrying mutations in the mitochondrial oli1 gene has been studied. DNA sequence analysis of this gene has been used to define the amino acid substitutions in subunit 9 of the mitochondrial ATPase complex. A domain of amino acids involved in oligomycin resistance can be recognized which encompasses residues in each of the two hydrophobic portions of the subunit 9 polypeptide that are thought to span the inner mitochondrial membrane. Certain amino acid substitutions also confer cross-resistance to venturicidin: these residues define an inner domain for venturicidin resistance. The expression of venturicidin resistance resulting from one particular substitution is modulated by nuclear genetic factors.

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Year:  1986        PMID： 2867935     DOI： 10.1016/0014-5793(86)80152-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

Review 1.  The c-Ring of the F1FO-ATP Synthase: Facts and Perspectives.

Authors:  Salvatore Nesci; Fabiana Trombetti; Vittoria Ventrella; Alessandra Pagliarani
Journal:  J Membr Biol       Date:  2015-11-30       Impact factor: 1.843

Review 2.  ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas.

Authors:  Sangjin Hong; Peter L Pedersen
Journal:  Microbiol Mol Biol Rev       Date:  2008-12       Impact factor: 11.056

3.  Mutations in the mitochondrial oli1 gene of Saccharomyces cerevisiae affecting subunit 9 of the mitochondrial ATPase complex.

Authors:  T A Willson; B G Ooi; H B Lukins; A W Linnane; P Nagley
Journal:  Nucleic Acids Res       Date:  1986-10-24       Impact factor: 16.971

4.  The oli1 gene and flanking sequences in mitochondrial DNA of Saccharomyces cerevisiae: the complete nucleotide sequence of a 1.35 kilobase petite mitochondrial DNA genome covering the oli1 gene.

Authors:  B G Ooi; P Nagley
Journal:  Curr Genet       Date:  1986       Impact factor: 3.886

5.  Manipulations in the peripheral stalk of the Saccharomyces cerevisiae F1F0-ATP synthase.

Authors:  Amanda K Welch; Caleb J Bostwick; Brian D Cain
Journal:  J Biol Chem       Date:  2011-01-21       Impact factor: 5.157

6.  Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase.

Authors:  A R Salomon; D W Voehringer; L A Herzenberg; C Khosla
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

Review 7.  The oligomycin axis of mitochondrial ATP synthase: OSCP and the proton channel.

Authors:  R J Devenish; M Prescott; G M Boyle; P Nagley
Journal:  J Bioenerg Biomembr       Date:  2000-10       Impact factor: 2.945

8.  The cytoplasmic loops of subunit a of Escherichia coli ATP synthase may participate in the proton translocating mechanism.

Authors:  Kyle J Moore; Christine M Angevine; Owen D Vincent; Brian E Schwem; Robert H Fillingame
Journal:  J Biol Chem       Date:  2008-03-12       Impact factor: 5.157

9.  Biogenesis of mitochondria: a mutation in the 5'-untranslated region of yeast mitochondrial oli1 mRNA leading to impairment in translation of subunit 9 of the mitochondrial ATPase complex.

Authors:  B G Ooi; H B Lukins; A W Linnane; P Nagley
Journal:  Nucleic Acids Res       Date:  1987-03-11       Impact factor: 16.971

10.  Oligomycin frames a common drug-binding site in the ATP synthase.

Authors:  Jindrich Symersky; Daniel Osowski; D Eric Walters; David M Mueller
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-06       Impact factor: 11.205
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