Literature DB >> 28678285

New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells.

Parikshit Moitra1, Krishan Kumar, Sourav Sarkar, Paturu Kondaiah, Wei Duan, Santanu Bhattacharya.   

Abstract

A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.

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Year:  2017        PMID： 28678285     DOI： 10.1039/c7cc03320f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Efficacious and sustained release of an anticancer drug mitoxantrone from new covalent organic frameworks using protein corona.

Authors:  Subhajit Bhunia; Pranay Saha; Parikshit Moitra; Matthew A Addicoat; Santanu Bhattacharya
Journal:  Chem Sci       Date:  2022-06-18       Impact factor: 9.969

2.  Cellular viability and osteogenic differentiation potential of human gingiva-derived stem cells in 2D culture following treatment with anionic, cationic, and neutral liposomes containing doxorubicin.

Authors:  Hyunjin Lee; Jihwan Son; Gawon Yi; Heebeom Koo; Jun-Beom Park
Journal:  Exp Ther Med       Date:  2018-09-19       Impact factor: 2.447
  2 in total

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