Literature DB >> 28677168

Impact of HLA-DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort.

B Oriol-Tordera1, A Llano1, C Ganoza2, S Cate3, W Hildebrand3, J Sanchez2,4,5, M L Calle6, C Brander1,6,7, A Olvera1.   

Abstract

Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads (P = .044) while DRB1*12:01 showed significantly lower viral set points (P = .015) and restricted a dominant T cell response to HIV Gag p24 (P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  CD4 T cell response; HIV susceptibility; HLA class II polymorphism; Peru; viral control

Mesh：

Substances：

Year:  2017        PMID： 28677168     DOI： 10.1111/tan.13085

Source DB:  PubMed          Journal:  HLA        ISSN： 2059-2302            Impact factor:   4.513


  3 in total

1.  Parallel Induction of CH505 B Cell Ontogeny-Guided Neutralizing Antibodies and tHIVconsvX Conserved Mosaic-Specific T Cells against HIV-1.

Authors:  Edmund G Wee; Nathifa A Moyo; Kevin O Saunders; Celia LaBranche; Filippo Donati; Silvia Capucci; Robert Parks; Nicola Borthwick; Zara Hannoun; David C Montefiori; Barton F Haynes; Tomáš Hanke
Journal:  Mol Ther Methods Clin Dev       Date:  2019-06-29       Impact factor: 6.698

2.  HLA-B*13, B*35 and B*39 Alleles Are Closely Associated With the Lack of Response to ART in HIV Infection: A Cohort Study in a Population of Northern Brazil.

Authors:  Leonn Mendes Soares Pereira; Eliane Dos Santos França; Iran Barros Costa; Erika Vanessa Oliveira Jorge; Patrícia Jeanne de Souza Mendonça Mattos; Amaury Bentes Cunha Freire; Francisco Lúzio de Paula Ramos; Talita Antonia Furtado Monteiro; Olinda Macedo; Rita Catarina Medeiros Sousa; Eduardo José Melo Dos Santos; Felipe Bonfim Freitas; Igor Brasil Costa; Antonio Carlos Rosário Vallinoto
Journal:  Front Immunol       Date:  2022-03-16       Impact factor: 7.561

3.  Novel Nested Peptide Epitopes Recognized by CD4+ T Cells Induced by HIV-1 Conserved-Region Vaccines.

Authors:  Nicola Borthwick; Sandra Silva-Arrieta; Anuska Llano; Masafumi Takiguchi; Christian Brander; Tomáš Hanke
Journal:  Vaccines (Basel)       Date:  2020-01-16
  3 in total

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