Literature DB >> 2867600

Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus.

J R Mancillas, G R Siggins, F E Bloom.   

Abstract

In rat hippocampal pyramidal cells tested in situ by iontophoresis of several neurotransmitters, ethanol significantly enhanced excitatory responses to acetylcholine and inhibitory responses to somatostatin-14 but had no statistically significant effect on excitatory responses to glutamate or inhibitory responses to gamma-aminobutyric acid or, in preliminary tests, to norepinephrine or serotonin. The effects of ethanol on responses to acetylcholine and somatostatin-14 may provide insight into synaptic mechanisms underlying the behavioral consequences of ethanol intoxication.

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Year:  1986        PMID： 2867600     DOI： 10.1126/science.2867600

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates.

Authors:  Kelly P Cosgrove; Tracy Kloczynski; Frederic Bois; Brian Pittman; Gilles Tamagnan; John P Seibyl; John H Krystal; Julie K Staley
Journal:  Synapse       Date:  2010-09       Impact factor: 2.562

2.  Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol.

Authors:  M J VanDoren; D B Matthews; G C Janis; A C Grobin; L L Devaud; A L Morrow
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

3.  Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area.

Authors:  B S Givens; G R Breese
Journal:  J Pharmacol Exp Ther       Date:  1990-08       Impact factor: 4.030

Review 4.  Central GABAergic systems and depressive illness.

Authors:  G Tunnicliff; E Malatynska
Journal:  Neurochem Res       Date:  2003-06       Impact factor: 3.996

5.  Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors.

Authors:  F J Wan; F Berton; S G Madamba; W Francesconi; G R Siggins
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

Review 6.  The association of alcoholism and anxiety.

Authors:  K T Brady; R B Lydiard
Journal:  Psychiatr Q       Date:  1993

7.  Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex.

Authors:  J R Mancillas; G R Siggins; F E Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

8.  Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder.

Authors:  Jake Valeri; Sinead M O'Donovan; Wei Wang; David Sinclair; Ratna Bollavarapu; Barbara Gisabella; Donna Platt; Craig Stockmeier; Harry Pantazopoulos
Journal:  Front Neurosci       Date:  2022-09-07       Impact factor: 5.152
  8 in total

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