Thiago César Lima1, Elizabete Bagordakis2, Saulo Gabriel Moreira Falci3, Cássio Roberto Rocha Dos Santos4, Marcos Luciano Pimenta Pinheiro5. 1. MSc Student, Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Brazil. 2. Postdoctoral Researcher, Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Brazil. 3. Adjunct Professor, Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Brazil. Electronic address: saulofalci@hotmail.com. 4. Professor, Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Brazil. 5. Adjunct Professor, Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Brazil.
Abstract
PURPOSE: We aimed to compare the effect of dexamethasone, 8 mg, and diclofenac sodium, 50 mg, associated with codeine, 50 mg, on the control of pain, swelling, and trismus after extraction of impacted third molars. MATERIALS AND METHODS:Fifteen healthy patients with a mean age of 22.8 years (SD, 12.62 years) received a single oral dose of either drug 1 hour before each surgical procedure (left and right teeth). At 24, 48, and 72 hours after surgery, swelling was determined by use of linear measurements on the face and trismus was determined by maximal mouth opening. Postoperative pain was self-recorded by the patients using a numerical rating scale at 24-hour intervals for a period of 72 hours. Data analysis involved descriptive statistics and Shapiro-Wilk, Wilcoxon, and paired t tests (P < .05). RESULTS:Dexamethasone controlled pain (P = .016) and edema (P = .08) within 48 hours better than diclofenac sodium associated with codeine. No statistically significant differences were found between drugs regarding trismus and consumption of rescue analgesics (acetaminophen). CONCLUSIONS: The results of this study suggest that pre-emptive administration of dexamethasone, 8 mg, showed better control of pain and swelling in bilateral extractions of third impacted mandibular molars.
RCT Entities:
PURPOSE: We aimed to compare the effect of dexamethasone, 8 mg, and diclofenac sodium, 50 mg, associated with codeine, 50 mg, on the control of pain, swelling, and trismus after extraction of impacted third molars. MATERIALS AND METHODS: Fifteen healthy patients with a mean age of 22.8 years (SD, 12.62 years) received a single oral dose of either drug 1 hour before each surgical procedure (left and right teeth). At 24, 48, and 72 hours after surgery, swelling was determined by use of linear measurements on the face and trismus was determined by maximal mouth opening. Postoperative pain was self-recorded by the patients using a numerical rating scale at 24-hour intervals for a period of 72 hours. Data analysis involved descriptive statistics and Shapiro-Wilk, Wilcoxon, and paired t tests (P < .05). RESULTS:Dexamethasone controlled pain (P = .016) and edema (P = .08) within 48 hours better than diclofenac sodium associated with codeine. No statistically significant differences were found between drugs regarding trismus and consumption of rescue analgesics (acetaminophen). CONCLUSIONS: The results of this study suggest that pre-emptive administration of dexamethasone, 8 mg, showed better control of pain and swelling in bilateral extractions of third impacted mandibular molars.
Authors: Chan Jong Chung; Seong Yeop Jeong; Joon Ho Jeong; Sung Wan Kim; Kyung Hyun Lee; Jeong Ho Kim; Sang Yoong Park; So Ron Choi Journal: Anesth Pain Med (Seoul) Date: 2021-04-15
Authors: Gustavo Antonio Correa Momesso; Gustavo Augusto Grossi-Oliveira; William Phillip Pereira Silva; Renan Akira; Fernando Chiba; Tárik Ocon Braga Polo; Tiburtino José de Lima Neto; Bárbara Ribeiro Rios; Ana Paula Farnezi Bassi; Doris Hissako Sumida; Michael Han; Michael Miloro; Leonardo Perez Faverani Journal: Sci Rep Date: 2021-12-27 Impact factor: 4.379