Chun-Chin Chang1,2,3, Chien-Yi Hsu2,3,4, Po-Hsun Huang5,2,3, Li-Kuo Liu6,7, Liang-Kung Chen6,7,8, Jaw-Wen Chen5,9,2,10, Shing-Jong Lin5,11,2,3,4. 1. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital Taoyuan Branch, Taoyuan, Taiwan. 2. Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan. 3. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. 4. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 5. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. 6. Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan. 7. Aging and Health Research Center, National Yang-Ming University, Taipei, Taiwan. 8. Institute of Public Health, National Yang-Ming University, Taipei, Taiwan. 9. Division of Clinical Research, Taipei Veterans General Hospital, Taipei, Taiwan. 10. Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan. 11. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Abstract
AIM: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. METHODS: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5%; mean age 64 ± 9 years, range 50-92 years). Assessment of frailty was based on the Cardiovascular Health Study criteria. Common carotid artery intima-media thickness (CIMT) was determined using carotid Doppler ultrasonography. RESULTS: Overall, 955 participants (53.1%) were non-frail, 724 (40.2%) were pre-frail and 119 (6.7%) were frail. Frail and pre-frail participants had significantly increased CIMT, high-sensitivity C-reactive protein, glycated hemoglobin and urine albumin-to-creatinine ratio, but had lower insulin-like growth factor-1 level and decreased femoral neck bone mineral density (BMD). By multivariate analysis, age (OR 2.53, 95% CI 1.92-3.33), C-reactive protein (OR 1.19, 95% CI 1.00-1.42), CIMT (OR 1.27, 95% CI 1.04-1.55) and femoral neck BMD (OR 0.49, 95% CI 0.38-0.65) were independently associated with frailty. CONCLUSIONS: The present study showed the epidemiology of frailty, and the strong connection to aging, increased CIMT, enhanced inflammation and decreased femoral neck BMD. These results suggested that preclinical atherosclerosis, inflammation and femoral neck BMD were potentially modifiable risk factors for frailty. Geriatr Gerontol Int 2017; 17: 2449-2454.
AIM: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. METHODS: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5%; mean age 64 ± 9 years, range 50-92 years). Assessment of frailty was based on the Cardiovascular Health Study criteria. Common carotid artery intima-media thickness (CIMT) was determined using carotid Doppler ultrasonography. RESULTS: Overall, 955 participants (53.1%) were non-frail, 724 (40.2%) were pre-frail and 119 (6.7%) were frail. Frail and pre-frail participants had significantly increased CIMT, high-sensitivity C-reactive protein, glycated hemoglobin and urine albumin-to-creatinine ratio, but had lower insulin-like growth factor-1 level and decreased femoral neck bone mineral density (BMD). By multivariate analysis, age (OR 2.53, 95% CI 1.92-3.33), C-reactive protein (OR 1.19, 95% CI 1.00-1.42), CIMT (OR 1.27, 95% CI 1.04-1.55) and femoral neck BMD (OR 0.49, 95% CI 0.38-0.65) were independently associated with frailty. CONCLUSIONS: The present study showed the epidemiology of frailty, and the strong connection to aging, increased CIMT, enhanced inflammation and decreased femoral neck BMD. These results suggested that preclinical atherosclerosis, inflammation and femoral neck BMD were potentially modifiable risk factors for frailty. Geriatr Gerontol Int 2017; 17: 2449-2454.
Authors: Douglas G J McKechnie; Meera Patel; A Olia Papacosta; Lucy T Lennon; Elizabeth A Ellins; Julian P J Halcox; Sheena E Ramsay; Peter H Whincup; S Goya Wannamethee Journal: BMC Geriatr Date: 2022-05-09 Impact factor: 4.070