Literature DB >> 28675406

DNA or protein? Capillary zone electrophoresis-mass spectrometry rapidly elucidates metallodrug binding selectivity.

Christian Artner1, Hannah U Holtkamp, Wolfgang Kandioller, Christian G Hartinger, Samuel M Meier-Menches, Bernhard K Keppler.   

Abstract

A novel capillary zone electrophoresis-mass spectrometry (CZE-MS) approach allows the simultaneous characterization and quantification of the binding of metal-based anticancer agents to biomolecules. Moreover, for the first time, oligonucleotide metallation was resolved at single-nucleotide resolution by MS.

Entities:  

Year:  2017        PMID: 28675406     DOI: 10.1039/c7cc04582d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

1.  Determination of Relative Stabilities of Metal-Peptide Bonds in the Gas Phase.

Authors:  Monika Cziferszky; Dianna Truong; Christian G Hartinger; Ronald Gust
Journal:  Chemistry       Date:  2021-10-21       Impact factor: 5.020

2.  The aqueous stability and interactions of organoruthenium compounds with serum proteins, cell culture medium, and human serum.

Authors:  Mie Riisom; Liam Eade; William D J Tremlett; Christian G Hartinger
Journal:  Metallomics       Date:  2022-07-25       Impact factor: 4.636

  2 in total

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