Kae-Woei Liang1,2,3, Wayne H-H Sheu2,4,5,6, Wen-Jane Lee7,8, Wen-Lieng Lee1,2, Chia-Po Fu4, Jun-Sing Wang2,4. 1. a Cardiovascular Center , Taichung Veterans General Hospital , Taichung , Taiwan. 2. b School of Medicine , National Yang Ming University , Taipei , Taiwan. 3. c Department of Medicine , China Medical University , Taichung , Taiwan. 4. d Division of Endocrinology and Metabolism, Department of Medicine , Taichung Veterans General Hospital , Taichung , Taiwan. 5. e Institute of Biomedical Sciences , National Chung Hsing University , Taichung , Taiwan. 6. f School of Medicine , National Defense Medical Center , Taipei , Taiwan. 7. g Department of Medical Research , Taichung Veterans General Hospital , Taichung , Taiwan. 8. h Tung-Hai University , Taichung , Taiwan.
Abstract
CONTEXT: Inflammation is one of the mechanisms underlying cardiac syndrome X (CSX). OBJECTIVES: Few studies have compared the expression of inflammatory or adhesion molecules between coronary artery disease (CAD) versus CSX. MATERIALS AND METHODS: Ninety-two CSX and 145 CAD subjects without known diabetes mellitus underwent coronary angiogram for angina. RESULTS: Vascular cell adhesion molecule (VCAM)-1 (median, 507 versus 431 ng/ml, p = 0.001) was significantly higher in the CAD group. In the binary regression, VCAM-1 was a significant differential factor for CAD versus CSX. DISCUSSION AND CONCLUSION: Adhesion molecules might be implicated in the differential expression of macro versus microvascular coronary disease. TRIAL REGISTRATION NUMBER: NCT01198730 at https://clinicaltrials.gov.
CONTEXT: Inflammation is one of the mechanisms underlying cardiac syndrome X (CSX). OBJECTIVES: Few studies have compared the expression of inflammatory or adhesion molecules between coronary artery disease (CAD) versus CSX. MATERIALS AND METHODS: Ninety-two CSX and 145 CAD subjects without known diabetes mellitus underwent coronary angiogram for angina. RESULTS:Vascular cell adhesion molecule (VCAM)-1 (median, 507 versus 431 ng/ml, p = 0.001) was significantly higher in the CAD group. In the binary regression, VCAM-1 was a significant differential factor for CAD versus CSX. DISCUSSION AND CONCLUSION: Adhesion molecules might be implicated in the differential expression of macro versus microvascular coronary disease. TRIAL REGISTRATION NUMBER: NCT01198730 at https://clinicaltrials.gov.
Authors: Miriam Peracaula; Daniela Torres; Paula Poyatos; Neus Luque; Eric Rojas; Anton Obrador; Ramon Orriols; Olga Tura-Ceide Journal: Life (Basel) Date: 2022-04-05