Acetylcholinesterase and somatostatin-immunoreactivity coexist in human neocortex.

Immunohistochemistry was combined with enzyme histochemistry to examine the localization of somatostatin (SOM) and acetylcholinesterase (AChE) in the human neocortex. Many of the SOM-immunoreactive cortical neurons were found to display specific AChE activity. Similar coexistence was seen in the rat cortex. In contrast, AChE and SOM appear to be present in distinct cell groups in the human caudate nucleus.