Selahattin Balsak1, Ayhan Kaydu2, Seyfettin Erdem3, M Fuat Alakus1, Zeynep Gursel Ozkurt4. 1. Diyarbakır Research and Education Hospital, Diyarbakir, Turkey. 2. Department of Anesthesiology, Diyarbakır Selahaddini Eyyübi State Hospital, 21100, Diyarbakir, Turkey. akaydu@hotmail.com. 3. Diyarbakir Bismil State Hospital, Diyarbakir, Turkey. 4. Dicle University Medical Faculty, Diyarbakir, Turkey.
Abstract
PURPOSE: To compare the efficacy of the fixed combination of brimonidine-timolol (FCBT) and the fixed combination of brinzolamide-timolol (FCBZT) treatments for elevated intraocular pressure (IOP) after phacoemulsification cataract surgery. METHODS: A randomised, prospective, double-blinded study was conducted on 277 eyes of 257 patients who underwentphacoemulsification cataract surgery. Patients were divided into three groups based on the medication administered after cataract surgery as follows: FCBT, FCBZT and a control group where no antiglaucoma medications were used. IOP was recorded at preoperative and postoperative hours 6 and 24 and days 3 and 5. RESULTS: No statistical differences were observed among the groups regarding age, sex and baseline IOP levels (p > 0.05). Mean IOP levels were significantly lower in the treatment groups than in the control group at postoperative hours 6 and 24 and days 3 and 5 (p < 0.001). Administration of one drop of FCBT or FCBZT demonstrated similar effects on preventing IOP spikes within 24 h of phacoemulsification cataract surgery. FCBZT more effectively lowered IOP than FCBT at days 3 and 5 (p < 0.05). CONCLUSIONS: We demonstrate that the postoperative administration of FCBT or FCBZT is effective in lowering IOP after phacoemulsification cataract surgery; FCBZT more effectively lowered IOP than FCBT at postoperative days 3 and 5.
RCT Entities:
PURPOSE: To compare the efficacy of the fixed combination of brimonidine-timolol (FCBT) and the fixed combination of brinzolamide-timolol (FCBZT) treatments for elevated intraocular pressure (IOP) after phacoemulsification cataract surgery. METHODS: A randomised, prospective, double-blinded study was conducted on 277 eyes of 257 patients who underwent phacoemulsification cataract surgery. Patients were divided into three groups based on the medication administered after cataract surgery as follows: FCBT, FCBZT and a control group where no antiglaucoma medications were used. IOP was recorded at preoperative and postoperative hours 6 and 24 and days 3 and 5. RESULTS: No statistical differences were observed among the groups regarding age, sex and baseline IOP levels (p > 0.05). Mean IOP levels were significantly lower in the treatment groups than in the control group at postoperative hours 6 and 24 and days 3 and 5 (p < 0.001). Administration of one drop of FCBT or FCBZT demonstrated similar effects on preventing IOP spikes within 24 h of phacoemulsification cataract surgery. FCBZT more effectively lowered IOP than FCBT at days 3 and 5 (p < 0.05). CONCLUSIONS: We demonstrate that the postoperative administration of FCBT or FCBZT is effective in lowering IOP after phacoemulsification cataract surgery; FCBZT more effectively lowered IOP than FCBT at postoperative days 3 and 5.
Authors: E Randy Craven; Thomas R Walters; Robert Williams; Connie Chou; Janet K Cheetham; Rhett Schiffman Journal: J Ocul Pharmacol Ther Date: 2005-08 Impact factor: 2.671
Authors: Anastasios G P Konstas; Gábor Holló; Anna-Bettina Haidich; Dimitrios G Mikropoulos; Theodoros Giannopoulos; Irini C Voudouragkaki; Eleni Paschalinou; Vassilios Konidaris; John R Samples Journal: J Ocul Pharmacol Ther Date: 2013-04-03 Impact factor: 2.671