Literature DB >> 2867485

(-)-Pindolol stereospecifically inhibits rat brain serotonin (5-HT) synthesis.

S Hjorth, A Carlsson.   

Abstract

(-)-Pindolol (4 mg/kg, i.p.) stereospecifically and selectively inhibited rat brain 5-HT synthesis. The DA and NA synthesis remained unaffected by pindolol (either enantiomer) treatment, and the (-)-pindolol-induced decrease in 5-HT synthesis was not prevented by reserpine pretreatment. The results indicate that, in addition to its beta-adrenergic properties, (-)-pindolol may act as an agonist at synthesis-controlling 5-HT receptors (autoreceptors ?) in the rat CNS.

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Year:  1985        PMID： 2867485     DOI： 10.1016/0028-3908(85)90207-2

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  8 in total

1.  Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis.

Authors:  C Moret; M Briley
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

2.  A mathematical model for paroxetine antidepressant effect time course and its interaction with pindolol.

Authors:  Berangere Gruwez; Alain Dauphin; Michel Tod
Journal:  J Pharmacokinet Pharmacodyn       Date:  2005-12       Impact factor: 2.745

3.  Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.

Authors:  P C Waldmeier; M Williams; P A Baumann; S Bischoff; M A Sills; R F Neale
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-06       Impact factor: 3.000

4.  Potentiation of DOI-induced forward locomotion in rats by (-)-pindolol pretreatment.

Authors:  P Kaur; S Ahlenius
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

5.  Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat.

Authors:  S Ahlenius; V Hillegaart; A Wijkström
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-05       Impact factor: 3.000

6.  Antagonism by pindolol, but not betaxolol, of 8-OH-DPAT-induced facilitation of male rat sexual behavior.

Authors:  S Ahlenius; K Larsson
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

7.  Prevention of the analgesic consequences of social defeat in male mice by 5-HT1A anxiolytics, buspirone, gepirone and ipsapirone.

Authors:  R J Rodgers; J K Shepherd
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

8.  Effects of chronic fluoxetine treatment in the presence and absence of (+/-)pindolol: a microdialysis study.

Authors:  L A Dawson; H Q Nguyen; D I Smith; L E Schechter
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739
  8 in total

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