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Literature DB >> 28674046

Repurposing Thiram and Disulfiram as Antibacterial Agents for Multidrug-Resistant Staphylococcus aureus Infections.

Abstract

Thiram and disulfiram were evaluated as antibacterial agents against multidrug-resistant Staphylococcus aureus Against a 30-member panel comprised of vancomycin-susceptible, vancomycin-intermediate, and vancomycin-resistant S. aureus strains, the MIC90 values of the respective test agents were 4 and 16 μg/ml. Additional analyses revealed that thiram and disulfiram are rapid-acting bacteriostatic agents with narrow, Gram-positive-bacterium spectrum activity. Synergy studies further determined that disulfiram increases the vancomycin susceptibility of three clinical vancomycin-resistant S. aureus strains in vitro, thus establishing a potential use in combination therapy.

Entities: Chemical Species

Keywords: MRSA; Staphylococcus aureus; VISA; VRSA; combination therapy; disulfiram; synergy; thiram; vancomycin

Mesh：

Substances：

Year: 2017 PMID： 28674046 PMCID： PMC5571293 DOI： 10.1128/AAC.00898-17

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

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11 in total

1. The Repurposed Drug Disulfiram Inhibits Urease and Aldehyde Dehydrogenase and Prevents In Vitro Growth of the Oomycete Pythium insidiosum.

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2. Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.

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Authors: Jordan G Sheppard; Keely R Frazier; Pushkar Saralkar; Mohammad F Hossain; Werner J Geldenhuys; Timothy E Long
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4. Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases.

Authors: Marco M Custodio; Jennifer Sparks; Timothy E Long
Journal: Antiinfect Agents Date: 2022-04-27

5. Disulfiram blocked cell entry of SARS-CoV-2 via inhibiting the interaction of spike protein and ACE2.

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6. Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701.

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7. Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides.

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Journal: Molecules Date: 2022-08-10 Impact factor: 4.927

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