| Literature DB >> 2867325 |
J Cuzick, D Y Wang, R D Bulbrook.
Abstract
The case for treating women at high risk of breast cancer with the anti-oestrogen tamoxifen is presented. This is a logical extension of a screening programme and is scientifically based on the effectiveness of tamoxifen in established disease, the relation between free oestradiol (and other hormone-related factors) to the risk of breast cancer, and the lack of side-effects from tamoxifen treatment. Choice of a high-risk group is critical; a specific trial protocol is outlined.Entities:
Mesh:
Substances:
Year: 1986 PMID: 2867325 DOI: 10.1016/s0140-6736(86)90729-4
Source DB: PubMed Journal: Lancet ISSN: 0140-6736 Impact factor: 79.321