Chalotte W Stecher1,2, Moussa Sacko3, Henry Madsen4, Shona Wilson5, Christian Wejse1,2, Adama D Keita6, Aly Landouré3, Mamadou S Traoré3, Per Kallestrup2, Eskild Petersen7, Birgitte Vennervald4. 1. Department of Infectious Diseases, Aarhus University Hospital, Denmark. 2. Center for Global Health (GloHAU), Department of Public Health, Aarhus University, Denmark. 3. Laboratory of Parasitology, Institut National de Recherche en Sante Publique, Bamako, Mali. 4. Section for Parasitology and Aquatic Diseases, SUND, University of Copenhagen, Denmark. 5. Department of Pathology, University of Cambridge, UK. 6. University of Sciences, Techniques and Technology, Bamako, Mali. 7. Department of Infectious Diseases, The Royal Hospital, P.O. Box 1331, Muscat, Sultanate of Oman and Institute for Clinical Medicine, University of Aarhus, Denmark.
Abstract
Background: The aim of this cross-sectional study was to investigate a possible association of Schistosoma haematobium with child growth development and describe a plausible schistosomiasis-related anemia in children and adults in a highly schistosomiasis endemic area of Mali. Methods: Urine, feces and blood samples from 399 participants of both sexes (2-40 years of age) were analyzed and supplemented by anthropometric measurements. Results: S. haematobium prevalence was 79.8%, S. mansoni 13.2% and Plasmodium falciparum 80.2%. S. haematobium infection intensity as five categories was significantly associated with anemia; i.e., odds of having anemia in the highest and the next highest category was 3.25 (95% CL 1.61-6.55; p<0.01) and 2.45 (95% CL 1.28-4.70; p<0.01), respectively, of that in the three lower categories combined after adjusting for age group and gender and the interaction between the two factors. Anemia was most pronounced in the 2-5 year olds males (55.5%, n=98). P. falciparum infection was not significantly associated with anemia. Stunting (body mass index [BMI] for age z-score<-2.00) was observed in 2.6% (2/78) of the 2-5 years olds and in 7.7% (14/182) in the 6-19 years age group. Lower BMI-z-scores (as continuous variable) were associated with anemia (p<0.05) while high intensity of S. haematobium infection was not significant when adjusting for age group and anemia. Participants with malaria infection had lower z-scores (as continuous variables) of weight and height for age. Lower height for age z-scores were also associated with anemia. Conclusions: S. haematobium infection is likely to impact on child growth and possibly also anemia in all age groups and advocates for inclusion of whole populations into future control programes.
Background: The aim of this cross-sectional study was to investigate a possible association of Schistosoma haematobium with child growth development and describe a plausible schistosomiasis-related anemia in children and adults in a highly schistosomiasis endemic area of Mali. Methods: Urine, feces and blood samples from 399 participants of both sexes (2-40 years of age) were analyzed and supplemented by anthropometric measurements. Results:S. haematobium prevalence was 79.8%, S. mansoni 13.2% and Plasmodium falciparum 80.2%. S. haematobium infection intensity as five categories was significantly associated with anemia; i.e., odds of having anemia in the highest and the next highest category was 3.25 (95% CL 1.61-6.55; p<0.01) and 2.45 (95% CL 1.28-4.70; p<0.01), respectively, of that in the three lower categories combined after adjusting for age group and gender and the interaction between the two factors. Anemia was most pronounced in the 2-5 year olds males (55.5%, n=98). P. falciparum infection was not significantly associated with anemia. Stunting (body mass index [BMI] for age z-score<-2.00) was observed in 2.6% (2/78) of the 2-5 years olds and in 7.7% (14/182) in the 6-19 years age group. Lower BMI-z-scores (as continuous variable) were associated with anemia (p<0.05) while high intensity of S. haematobium infection was not significant when adjusting for age group and anemia. Participants with malaria infection had lower z-scores (as continuous variables) of weight and height for age. Lower height for age z-scores were also associated with anemia. Conclusions: S. haematobium infection is likely to impact on child growth and possibly also anemia in all age groups and advocates for inclusion of whole populations into future control programes.
Authors: Nobuyuki Mishima; Samuel K Jemu; Tomoaki Kuroda; Koichiro Tabuchi; Andrew W Darcy; Takaki Shimono; Pheophet Lamaningao; Mari Miyake; Seiji Kanda; Susan Ng'ambi; Yoshihiro Komai; Hirofumi Maeba; Hiroyuki Amano; Toshimasa Nishiyama Journal: Trop Med Health Date: 2019-05-02
Authors: Ngoy Mutombo; Aly Landouré; Wing Young Man; Alan Fenwick; Robert Dembélé; Moussa Sacko; Adama D Keita; Mamadou S Traoré; Joanne P Webster; Mary-Louise McLaws Journal: Acta Trop Date: 2019-07-26 Impact factor: 3.112