| Literature DB >> 28671330 |
Melissa R Berg1,2, Michael A Owston1, Marie-Claire Gauduin1,3, Basel T Assaf2, Anne D Lewis2, Edward J Dick1.
Abstract
Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.Entities:
Keywords: cytomegalovirus; inclusions; intra-cytoplasmic; intranuclear; model; non-human primate; pituitary; viral
Mesh:
Year: 2017 PMID: 28671330 PMCID: PMC5673561 DOI: 10.1111/jmp.12289
Source DB: PubMed Journal: J Med Primatol ISSN: 0047-2565 Impact factor: 0.667