Literature DB >> 28671302

Superoxide Dismutase-Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain.

Sonia Kartha1, Lesan Yan1, Christine L Weisshaar1, Meagan E Ita1, Vladimir V Shuvaev2, Vladimir R Muzykantov2, Andrew Tsourkas1, Beth A Winkelstein1, Zhiliang Cheng1.   

Abstract

A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated antioxidant enzyme SOD. In vivo studies in the rat demonstrate that administration of SOD-encapsulated porous polymersomes can prevent neuropathic pain after nerve root compression more effectively than treatment with free antioxidant enzyme alone.
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  antioxidants; neuropathic pain; porous polymersomes; superoxide dismutase

Mesh：

Substances：

Year:  2017        PMID： 28671302      PMCID： PMC5591629          DOI： 10.1002/adhm.201700500

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  56 in total

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3.  Lecithinized superoxide dismutase (PC-SOD) improved spinal cord injury-induced motor dysfunction through suppression of oxidative stress and enhancement of neurotrophic factor production.

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4.  Anti-hyperalgesic and anti-nociceptive potentials of standardized grape seed proanthocyanidin extract against CCI-induced neuropathic pain in rats.

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5.  The prevalence of neuropathic pain: clinical evaluation compared with screening tools in a community population.

Authors:  Barbara P Yawn; Peter C Wollan; Toby N Weingarten; James C Watson; W Michael Hooten; L Joseph Melton
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7.  Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats.

Authors:  Shayne N Hassler; Kathia M Johnson; Claire E Hulsebosch
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Review 8.  Opioids for neuropathic pain.

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10.  Supression of chronic central pain by superoxide dismutase in rats with spinal cord injury: Inhibition of the NMDA receptor implicated.

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  12 in total

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2.  Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy.

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Review 4.  Nanotherapeutic-directed approaches to analgesia.

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Review 6.  Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix.

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7.  Grading facial expression is a sensitive means to detect grimace differences in orofacial pain in a rat model.

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8.  Combination therapy with ropivacaine-loaded liposomes and nutrient deprivation for simultaneous cancer therapy and cancer pain relief.

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Review 9.  Superoxide Dismutase Administration: A Review of Proposed Human Uses.

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Journal:  Molecules       Date:  2021-03-25       Impact factor: 4.411

10.  Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling.

Authors:  Peter J Altshuler; Alexis R Schiazza; Lijun Luo; Mark R Helmers; Bonirath Chhay; Jason J Han; Robin Hu; D Alan Herbst; Andrew Tsourkas; Zhiliang Cheng; Pavan Atluri
Journal:  Adv Ther (Weinh)       Date:  2021-04-23
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