Literature DB >> 28671289

Mechanistic Characterization of Two Chimeric Sesterterpene Synthases from Penicillium.

Takaaki Mitsuhashi1, Jan Rinkel2, Masahiro Okada1, Ikuro Abe1, Jeroen S Dickschat2.   

Abstract

The products of two bifunctional fungal sesterterpene synthases (StTPS), with prenyl transferase (PT) and terpene synthase (TPS) domains from Penicillium, were structurally characterized and their mechanisms studied in detail by labeling experiments. A phylogenetic analysis of the TPS domains of the new and previously characterized enzymes revealed six distinct clades. Enzymes from the same clade catalyze a common initial cyclization step, which suggests the potential for structural predictions from amino acid sequences.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  biosynthesis; carbocations; enzyme mechanisms; isotopes; terpenes

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Year:  2017        PMID： 28671289     DOI： 10.1002/chem.201702766

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  10 in total

1.  Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach.

Authors:  Lan Jiang; Huanting Yang; Xue Zhang; Xiaoying Li; Kangjie Lv; Weiyan Zhang; Guoliang Zhu; Chengwei Liu; Yongheng Wang; Tom Hsiang; Lixin Zhang; Xueting Liu
Journal:  Appl Microbiol Biotechnol       Date:  2022-08-30       Impact factor: 5.560

2.  Deceptive Complexity in Formation of Cleistantha-8,12-diene.

Authors:  Jin Liang; Amy T Merrill; Croix J Laconsay; Anwei Hou; Qingyu Pu; Jeroen S Dickschat; Dean J Tantillo; Qiang Wang; Reuben J Peters
Journal:  Org Lett       Date:  2022-04-06       Impact factor: 6.072

3.  Mechanistic Studies on Trichoacorenol Synthase from Amycolatopsis benzoatilytica.

Authors:  Jan Rinkel; Jeroen S Dickschat
Journal:  Chembiochem       Date:  2019-11-07       Impact factor: 3.164

4.  A Family of Related Fungal and Bacterial Di- and Sesterterpenes: Studies on Fusaterpenol and Variediene.

Authors:  Jan Rinkel; Simon T Steiner; Guangkai Bian; Rong Chen; Tiangang Liu; Jeroen S Dickschat
Journal:  Chembiochem       Date:  2019-11-07       Impact factor: 3.164

5.  On the mass spectrometric fragmentations of the bacterial sesterterpenes sestermobaraenes A-C.

Authors:  Anwei Hou; Jeroen S Dickschat
Journal:  Beilstein J Org Chem       Date:  2020-11-19       Impact factor: 2.883

6.  Enzymatic Synthesis of Variediene Analogs.

Authors:  Lin-Fu Liang; Jeroen S Dickschat
Journal:  Chemistry       Date:  2022-02-09       Impact factor: 5.020

7.  Mechanism of the Bifunctional Multiple Product Sesterterpene Synthase AcAS from Aspergillus calidoustus.

Authors:  Zhiyang Quan; Anwei Hou; Bernd Goldfuss; Jeroen S Dickschat
Journal:  Angew Chem Int Ed Engl       Date:  2022-02-04       Impact factor: 16.823

8.  Enzymatic Synthesis of Methylated Terpene Analogues Using the Plasticity of Bacterial Terpene Synthases.

Authors:  Anwei Hou; Lukas Lauterbach; Jeroen S Dickschat
Journal:  Chemistry       Date:  2020-01-30       Impact factor: 5.236

9.  The Biosynthetic Gene Cluster for Sestermobaraenes-Discovery of a Geranylfarnesyl Diphosphate Synthase and a Multiproduct Sesterterpene Synthase from Streptomyces mobaraensis.

Authors:  Anwei Hou; Jeroen S Dickschat
Journal:  Angew Chem Int Ed Engl       Date:  2020-08-31       Impact factor: 15.336

10.  Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis.

Authors:  Rong Chen; Qidong Jia; Xin Mu; Ben Hu; Xiang Sun; Zixin Deng; Feng Chen; Guangkai Bian; Tiangang Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2021-07-20       Impact factor: 11.205
  10 in total

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