Literature DB >> 28671057

Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets.

Maria Elizbeth Alvarez-Sanchez1, Jose Luis Villalpando1, Laura Itzel Quintas-Granados1, Rossana Arroyo2.   

Abstract

Polyamines are essential for many biological processes in all organisms. Here we show a current landscape of studies and strategies implemented for the study of polyamine metabolism, as well as molecular aspects that implicate the role of key enzymes, transport proteins, inhibitors, and the study of novel molecules as potential therapeutic targets. This review focused on the synthesis, interconversion and function of these molecules in Trichomonas vaginalis, a common sexually transmitted parasite of humans. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Hypusination machinery; Trichomonas vaginalis; ornithine decarboxylase (ODC); polyamine oxidase (PAO); polyamines; putrescine; spermidine; spermine

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Year:  2017        PMID： 28671057     DOI： 10.2174/1381612823666170703162754

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  3 in total

1.  Proteomic profile approach of effect of putrescine depletion over Trichomonas vaginalis.

Authors:  María Elizbeth Alvarez-Sánchez; Laura Itzel Quintas-Granados; Laura Isabel Vázquez-Carrillo; Jonathan Puente-Rivera; Alma Villalobos-Osnaya; María Dolores Ponce-Regalado; Minerva Camacho-Nuez
Journal:  Parasitol Res       Date:  2018-03-07       Impact factor: 2.289

Review 2.  Polyamines in protozoan pathogens.

Authors:  Margaret A Phillips
Journal:  J Biol Chem       Date:  2018-10-17       Impact factor: 5.157

3.  Chemical composition, immunostimulatory, cytotoxic and antiparasitic activities of the essential oil from Brazilian red propolis.

Authors:  Ângela Sena-Lopes; Francisco Silvestre Brilhante Bezerra; Raquel Nascimento das Neves; Rodrigo Barros de Pinho; Mara Thais de Oliveira Silva; Lucielli Savegnago; Tiago Collares; Fabiana Seixas; Karine Begnini; João Antonio Pêgas Henriques; Mariana Roesch Ely; Luciane C Rufatto; Sidnei Moura; Thiago Barcellos; Francine Padilha; Odir Dellagostin; Sibele Borsuk
Journal:  PLoS One       Date:  2018-02-01       Impact factor: 3.240
  3 in total

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