Literature DB >> 28670717

Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis.

M Furue1,2, K Yamamura1, M Kido-Nakahara1, T Nakahara1, Y Fukui3,4.   

Abstract

Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH 2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH 2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.
© 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Entities:  

Keywords:  T helper 2; atopic dermatitis; interleukin-31; interleukin-31 receptor; pruritus

Mesh：

Substances：

Year:  2017        PMID： 28670717     DOI： 10.1111/all.13239

Source DB:  PubMed          Journal:  Allergy        ISSN： 0105-4538            Impact factor:   13.146


  55 in total

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Authors:  Kinga Gortel
Journal:  Can Vet J       Date:  2018-09       Impact factor: 1.008

Review 2.  The use of biologics for immune modulation in allergic disease.

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Journal:  J Clin Invest       Date:  2019-03-18       Impact factor: 14.808

3.  Oncostatin M and its role in fibrosis.

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Journal:  Immunology       Date:  2019-10-01       Impact factor: 7.397

Review 5.  [New aspects in systemic treatment of atopic dermatitis].

Authors:  T Werfel; A Wollenberg; T Pumnea; A Heratizadeh
Journal:  Hautarzt       Date:  2018-03       Impact factor: 0.751

6.  The Itch-Scratch Cycle: A Review of the Mechanisms.

Authors:  Giulia Rinaldi
Journal:  Dermatol Pract Concept       Date:  2019-04-30

Review 7.  Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?

Authors:  Helen A Brough; Kari C Nadeau; Sayantani B Sindher; Shifaa S Alkotob; Susan Chan; Henry T Bahnson; Donald Y M Leung; Gideon Lack
Journal:  Allergy       Date:  2020-05-18       Impact factor: 13.146

Review 8.  The Role of the Environment and Exposome in Atopic Dermatitis.

Authors:  Nicholas Stefanovic; Alan D Irvine; Carsten Flohr
Journal:  Curr Treat Options Allergy       Date:  2021-05-21

Review 9.  Immunological Aspects of Skin Aging in Atopic Dermatitis.

Authors:  Georgeta St Bocheva; Radomir M Slominski; Andrzej T Slominski
Journal:  Int J Mol Sci       Date:  2021-05-27       Impact factor: 5.923

Review 10.  A New Generation of Treatments for Itch.

Authors:  Emilie Fowler; Gil Yosipovitch
Journal:  Acta Derm Venereol       Date:  2020-01-07       Impact factor: 3.875
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