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Literature DB >> 2867028

Inhibition of lipopolysaccharide mitogenicity with characterized anti-lipid A monoclonal antibodies.

Abstract

Antibodies to lipid A were raised in mice immunized with non-hydrolysed Bordetella pertussis microorganisms, coated with lipid A isolated from the same bacteria. Anti-lipid A activity of immune sera was measured by radioimmunoassay. Four hybrid cell lines that secrete antibodies directed against the hydrophobic region of B. pertussis lipopolysaccharide were produced by cell fusion between myeloma cells and spleen cells from immunized C3H/He-PAS mice. Differences were observed in the potency of the isolated monoclonal antibodies to inhibit B cell proliferation induced by lipopolysaccharide (LPS) or by lipid A, suggesting a selective recognition of effector sites present on the hydrophobic region of LPS.

Entities: Chemical Disease Species

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Year: 1985 PMID： 2867028 PMCID： PMC1453740

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

28 in total

1. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

Authors: P L Ey; S J Prowse; C R Jenkin
Journal: Immunochemistry Date: 1978-07

2. Glutaraldehyde-activated aminohexyl- derivative of Sepharose 4B as a new verstile immunoabsorbent.

Authors: C L Cambiaso; A Goffinet; J P Vaerman; J F Heremans
Journal: Immunochemistry Date: 1975-04

3. A better cell line for making hybridomas secreting specific antibodies.

Authors: M Shulman; C D Wilde; G Köhler
Journal: Nature Date: 1978-11-16 Impact factor: 49.962

4. Determination of anti-lipid A and lipid A by enzyme immunoassay.

Authors: P C Fink; C Galanos
Journal: Immunobiology Date: 1981 Impact factor: 3.144

5. Lipid A from endotoxin: antigenic activities of purified fractions in liposomes.

Authors: B Banerji; C R Alving
Journal: J Immunol Date: 1979-12 Impact factor: 5.422

6. A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1.

Authors: R Kannagi; E Nudelman; S B Levery; S Hakomori
Journal: J Biol Chem Date: 1982-12-25 Impact factor: 5.157

Review 2. Immunoprophylaxis and immunotherapy of gram-negative sepsis and shock with antibodies to core glycolipids and lipid A of bacterial lipopolysaccharides.

Authors: I G Mitov; D G Terziiski
Journal: Infection Date: 1991 Nov-Dec Impact factor: 3.553

3. A synthetic analog of the 3-deoxy-D-manno-2-octulosonic acid disaccharide moiety of rough-type endotoxins does not bind to mouse peritoneal macrophages and human monocytes.

Authors: R Girard; T Pedron; P Kosma; R Chaby
Journal: Infect Immun Date: 1993-09 Impact factor: 3.441

3 in total

Inhibition of lipopolysaccharide mitogenicity with characterized anti-lipid A monoclonal antibodies.

1. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

2. Glutaraldehyde-activated aminohexyl- derivative of Sepharose 4B as a new verstile immunoabsorbent.

3. A better cell line for making hybridomas secreting specific antibodies.

4. Determination of anti-lipid A and lipid A by enzyme immunoassay.

5. Lipid A from endotoxin: antigenic activities of purified fractions in liposomes.

6. A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen SSEA-1.

7. Lipid A antiserum-mediated protection against lipopolysaccharide- and lipid A-induced fever and skin necrosis.

8. Monoclonal antibodies against Vibrio cholerae lipopolysaccharide.

9. Study of the idiotypy of lipopolysaccharide-specific polyclonal and monoclonal antibodies.

10. Immunogenic properties of lipid A.

1. Characterization of the epitope specificity of murine monoclonal antibodies directed against lipid A.

Review 2. Immunoprophylaxis and immunotherapy of gram-negative sepsis and shock with antibodies to core glycolipids and lipid A of bacterial lipopolysaccharides.

3. A synthetic analog of the 3-deoxy-D-manno-2-octulosonic acid disaccharide moiety of rough-type endotoxins does not bind to mouse peritoneal macrophages and human monocytes.