Literature DB >> 28669856

Topoisomerase IIβ and its role in different biological contexts.

V Satish Bollimpelli1, Pankaj S Dholaniya1, Anand K Kondapi2.   

Abstract

Topoisomerase IIβ is a type II DNA topoisomerase that was reported to be expressed in all mammalian cells but abundantly expressed in cells that have undergone terminal differentiation to attain a post mitotic state. Enzymatically it catalyzes ATP-dependent topological changes of double stranded DNA, while as a protein it was reported to be associated with several factors in promoting cell growth, migration, DNA repair and transcription regulation. The cellular roles of topoisomerase IIβ are very less understood compared to its counterpart topoisomerase IIα. This review discusses origin of Topoisomerase II beta, its structure, activities reported in vitro and in vivo along with implications in cellular processes namely transcription, DNA repair, neuronal development, aging, HIV-infection and cancer.
Copyright © 2017. Published by Elsevier Inc.

Entities:  

Keywords:  Aging; Cancer; DNA repair; HIV; Neuron; Transcription

Mesh：

Substances：

Year:  2017        PMID： 28669856     DOI： 10.1016/j.abb.2017.06.021

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  8 in total

1.  Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway.

Authors:  Jian Chen; Wenjuan Li; Ke Cui; Kaiyuan Ji; Shuxiang Xu; Yang Xu
Journal:  Oncogene       Date:  2018-05-24       Impact factor: 9.867

2.  Evolutionary History of TOPIIA Topoisomerases in Animals.

Authors:  Filipa Moreira; Miguel Arenas; Arnaldo Videira; Filipe Pereira
Journal:  J Mol Evol       Date:  2022-02-14       Impact factor: 2.395

3.  FGF-2b and h-PL Transform Duct and Non-Endocrine Human Pancreatic Cells into Endocrine Insulin Secreting Cells by Modulating Differentiating Genes.

Authors:  Giulia Donadel; Donatella Pastore; David Della-Morte; Barbara Capuani; Marco F Lombardo; Francesca Pacifici; Marco Bugliani; Fabio A Grieco; Piero Marchetti; Davide Lauro
Journal:  Int J Mol Sci       Date:  2017-10-25       Impact factor: 5.923

Review 4.  Recent developments in topoisomerase-targeted cancer chemotherapy.

Authors:  KirkE Hevener; Tatsiana A Verstak; Katie E Lutat; Daniel L Riggsbee; Jeremiah W Mooney
Journal:  Acta Pharm Sin B       Date:  2018-07-25       Impact factor: 11.413

5.  Transcriptome-wide N6-methyladenine methylation in granulosa cells of women with decreased ovarian reserve.

Authors:  Chang Liu; Linshuang Li; Bo Yang; Yiqing Zhao; Xiyuan Dong; Lixia Zhu; Xinling Ren; Bo Huang; Jing Yue; Lei Jin; Hanwang Zhang; Lan Wang
Journal:  BMC Genomics       Date:  2022-03-28       Impact factor: 3.969

6.  Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs.

Authors:  Maral Ramazani; Razieh Pourahmad Jaktaji; Farshad H Shirazi; Maria Tavakoli-Ardakani; Ahmad Salimi; Jalal Pourahmad
Journal:  BMC Pharmacol Toxicol       Date:  2019-12-02       Impact factor: 2.483

7.  Clinical significance of topoisomerase-II expression in patients with advanced non-small cell lung cancer treated with amrubicin.

Authors:  Reiko Sakurai; Kyoichi Kaira; Yosuke Miura; Noriaki Sunaga; Ryusei Saito; Tetsunari Oyama; Takeshi Hisada; Masanobu Yamada
Journal:  Thorac Cancer       Date:  2020-01-03       Impact factor: 3.500

8.  Substituted 4,5'-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase IIα.

Authors:  Kaja Bergant Loboda; Matej Janežič; Martina Štampar; Bojana Žegura; Metka Filipič; Andrej Perdih
Journal:  J Chem Inf Model       Date:  2020-06-22       Impact factor: 4.956
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.