| Literature DB >> 28669750 |
Steven Goossens1, Niels Vandamme2, Pieter Van Vlierberghe3, Geert Berx4.
Abstract
Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly accepted as a core component of carcinoma progression. Collectively, EMT and transcription factors (EMT-TFs) of the ZEB, SNAIL and TWIST families are quoted in the same breath for nearly 20years. Recent work on these EMT-TFs has extended their scope, and their typical definition as EMT-inducing factors has become out-of-date. New insights have warranted a re-evaluation of these transcription factors and their pleiotropic functions in physiological and pathological conditions, not solely limited to cell invasion and dissemination.Entities:
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Year: 2017 PMID： 28669750 DOI： 10.1016/j.bbcan.2017.06.006
Source DB: PubMed Journal: Biochim Biophys Acta Rev Cancer ISSN： 0304-419X Impact factor: 10.680