Literature DB >> 2866973

Sensitivity to dynorphin-(1-13) of the presynaptic inhibitory opiate receptors of the guinea-pig heart.

F Ledda, L Mantelli, V Corti.   

Abstract

Dynorphin-(1-13) at the concentrations of 1-10 microM, produced a dose-dependent inhibition of the cardiac response to field stimulation of the adrenergic nerve terminals in guinea-pig atria pretreated with peptidase inhibitors. This inhibitory effect was competitively antagonized in a dose-dependent manner by 5 and 10 microM naloxone. Since dynorphin-(1-13) did not modify the dose-inotropic effect curve of exogenous noradrenaline, it was concluded that the depressant effect of the opioid agonist was due to the stimulation of the presynaptic inhibitory opiate receptors belonging to the kappa subtype.

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Year:  1985        PMID： 2866973     DOI： 10.1016/0014-2999(85)90013-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Possible regulatory role of dynorphin A in the urinary bladder.

Authors:  A Berggren; A Dahlström; A Rubenson; U Sillén
Journal:  J Neural Transm Gen Sect       Date:  1992

2.  Effect of dynorphin A(1-13) on cardiomyocytes in culture: modulation of the response to increased extracellular calcium, but no effect on intrinsic cardiac contractile frequency or the response to isoproterenol or increased extracellular potassium.

Authors:  S W Rabkin
Journal:  Basic Res Cardiol       Date:  1992 May-Jun       Impact factor: 17.165

Review 3.  Electrical neurostimulators for pain relief in angina.

Authors:  J E Sanderson
Journal:  Br Heart J       Date:  1990-03

4.  Influence of naloxone on the effects of high frequency transcutaneous electrical nerve stimulation in angina pectoris induced by atrial pacing.

Authors:  C Mannheimer; H Emanuelsson; F Waagstein; C Wilhelmsson
Journal:  Br Heart J       Date:  1989-07

5.  Different effects of prostaglandins on adrenergic neurotransmission in atrial and ventricular preparations.

Authors:  L Mantelli; S Amerini; F Ledda
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

6.  Blockade of alpha 2-adrenoceptors permits the operation of otherwise silent opioid kappa-receptors at the sympathetic axons of rabbit jejunal arteries.

Authors:  D Ramme; P Illes; L Späth; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-09       Impact factor: 3.000

Review 7.  Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists.

Authors:  Leonid N Maslov; Igor Khaliulin; Peter R Oeltgen; Natalia V Naryzhnaya; Jian-Ming Pei; Stephen A Brown; Yury B Lishmanov; James M Downey
Journal:  Med Res Rev       Date:  2016-05-16       Impact factor: 12.944
  7 in total

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