Inchirah Karmous1, Jiří Plesník2, Amira Sayed Khan3, Omar Šerý4, Abdelmajid Abid5, Amani Mankai6, Abdellah Aouidet6, Naim Akhtar Khan7. 1. Higher School of Health and Technical Sciences, Tunis El Manar University, Tunisia; Physiologie de la Nutrition & Toxicologie, INSERM UMR 1231, Université de Bourgogne-Franche Comté (UBFC), Dijon, France; Faculté des Sciences de Bizerte, Jarzouna-Bizerte, Tunisia. 2. Physiologie de la Nutrition & Toxicologie, INSERM UMR 1231, Université de Bourgogne-Franche Comté (UBFC), Dijon, France; Laboratory of Neurobiology and Molecular Psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic. 3. Physiologie de la Nutrition & Toxicologie, INSERM UMR 1231, Université de Bourgogne-Franche Comté (UBFC), Dijon, France; Département de Biochimie, Biologie Cellulaire et Moléculaire, Université des Frères Mentouri, Constantine 1, Alegria. 4. Laboratory of Neurobiology and Molecular Psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic; Institute of Animal Physiology and Genetics, Academy of Science, Brno, Czech Republic. 5. Institut National de Nutrition et de Technologie Alimentaire de Tunis, Djebel Lakhdar, Bab Saadoun, Tunis, Tunisia. 6. Higher School of Health and Technical Sciences, Tunis El Manar University, Tunisia. 7. Physiologie de la Nutrition & Toxicologie, INSERM UMR 1231, Université de Bourgogne-Franche Comté (UBFC), Dijon, France. Electronic address: Naim.Khan@u-bourgogne.fr.
Abstract
BACKGROUND & AIMS: We assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects. DESIGN: The normal weight (n = 52, age = 35.3 ± 4.10 years, BMI = 23.22 ± 1.44 kg/m2) and obese (n = 52, age = 35.0 ± 5.43 years, BMI = 34.29 ± 5.31 kg/m2) participants were recruited to determine fat and bitter detection thresholds. The genomic DNA was used to determine single nucleotide polymorphism (SNP) of CD36 (rs1761667) and TAS2R38 (rs1726866 and rs10246939). RESULTS: The study included the participants who could detect LA, i.e., lipid-tasters. There was a positive correlation between BMI and detection thresholds for fat and bitter taste in normal weight and obese subjects. Obese participants showed a positive correlation between LA and PROP detection thresholds. PROP detection thresholds were higher for CD36 SNP (rs1761667) and TAS2R38 SNPs (rs1726866 and rs10246939) in obese participants compared to normal weight subjects. LA detection thresholds were not high for CD36 SNP (rs1761667) or TAS2R38 SNP (rs1726866 and rs10246939) in obese participants. CONCLUSIONS: Orosensory detection thresholds for fat and bitter taste are associated with BMI, and CD36 and TAS2R38 genotypes are not always associated with taste phenotypes.
BACKGROUND & AIMS: We assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects. DESIGN: The normal weight (n = 52, age = 35.3 ± 4.10 years, BMI = 23.22 ± 1.44 kg/m2) and obese (n = 52, age = 35.0 ± 5.43 years, BMI = 34.29 ± 5.31 kg/m2) participants were recruited to determine fat and bitter detection thresholds. The genomic DNA was used to determine single nucleotide polymorphism (SNP) of CD36 (rs1761667) and TAS2R38 (rs1726866 and rs10246939). RESULTS: The study included the participants who could detect LA, i.e., lipid-tasters. There was a positive correlation between BMI and detection thresholds for fat and bitter taste in normal weight and obese subjects. Obeseparticipants showed a positive correlation between LA and PROP detection thresholds. PROP detection thresholds were higher for CD36 SNP (rs1761667) and TAS2R38 SNPs (rs1726866 and rs10246939) in obeseparticipants compared to normal weight subjects. LA detection thresholds were not high for CD36 SNP (rs1761667) or TAS2R38 SNP (rs1726866 and rs10246939) in obeseparticipants. CONCLUSIONS: Orosensory detection thresholds for fat and bitter taste are associated with BMI, and CD36 and TAS2R38 genotypes are not always associated with taste phenotypes.
Authors: Omar Šerý; Tomáš Zeman; Kateřina Sheardová; Martin Vyhnálek; Hana Marková; Jan Laczó; Jan Lochman; Petr Kralik; Kamila Vrzalová; Radka Dziedzinska; Vladimir J Balcar; Jakub Hort Journal: Sci Rep Date: 2022-06-29 Impact factor: 4.996
Authors: Habiba Bajit; O Ait Si Mohammed; Y Guennoun; S Benaich; E Bouaiti; H Belghiti; M Mrabet; E M Elfahime; N E El Haloui; N Saeid; K El Kari; A Hichami; N A Khan; H Benkirane; H Aguenaou Journal: J Nutr Sci Date: 2020-06-30