Pham Cam Phuong1, Nguyen Duc Luan2, Vo Thi Huyen Trang2, Steven E Schild3, Dirk Rades4,5, Mai Trong Khoa2,5. 1. The Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam phamcamphuong@gmail.com. 2. The Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam. 3. Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A. 4. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. 5. Department of Nuclear Medicine, Ha Noi Medical University, Hanoi, Vietnam.
Abstract
AIM: To evaluate the value of radiosurgery with a rotating gamma-system (RGS) for cerebral cavernomas. PATIENTS AND METHODS: Seventy-nine patients with symptomatic cerebral cavernomas underwent RGS radiosurgery at the Bach Mai Hospital, Hanoi, Vietnam. Median dose (single fraction) was 20 Gy (range=14-26 Gy). Endpoints included effect on headache, seizures and tumor size. RESULTS: Of 60 patients with headache, 17% had complete response, 82% partial response and 2% stable disease (best response). Of 39 patients with seizures, 31% had complete response, 64% partial response and 5% stable disease. Four patients developed recurrent seizures after 1 year. Regarding the size of cavernoma at 15 months, complete response was observed in 6%, partial response in 75%, stable disease in 15%, progression in 1% and pseudo-progression in 3% of patients. Bleeding within 2 years after RGS radiosurgery occurred in only five patients (6%). RGS dose had no significant impact on outcomes. CONCLUSION: RGS radiosurgery provided very high rates of symptom relief in patients with cerebral cavernomas. Copyright
AIM: To evaluate the value of radiosurgery with a rotating gamma-system (RGS) for cerebral cavernomas. PATIENTS AND METHODS: Seventy-nine patients with symptomatic cerebral cavernomas underwent RGS radiosurgery at the Bach Mai Hospital, Hanoi, Vietnam. Median dose (single fraction) was 20 Gy (range=14-26 Gy). Endpoints included effect on headache, seizures and tumor size. RESULTS: Of 60 patients with headache, 17% had complete response, 82% partial response and 2% stable disease (best response). Of 39 patients with seizures, 31% had complete response, 64% partial response and 5% stable disease. Four patients developed recurrent seizures after 1 year. Regarding the size of cavernoma at 15 months, complete response was observed in 6%, partial response in 75%, stable disease in 15%, progression in 1% and pseudo-progression in 3% of patients. Bleeding within 2 years after RGS radiosurgery occurred in only five patients (6%). RGS dose had no significant impact on outcomes. CONCLUSION: RGS radiosurgery provided very high rates of symptom relief in patients with cerebral cavernomas. Copyright