BACKGROUND/AIM: Thrombospondin-1 (TSP1) is correlated with carcinogenesis occurring in cases of intestinal inflammation. The aim of this study was to clarify the role of TSP1 in gastric carcinogenesis. MATERIALS AND METHODS: A total of 39 patients with gastric cancer who had undergone gastrectomy were enrolled. The expression of TSP1 mRNA in non-cancer tissues was determined. Furthermore, the expression of CD36, STAT3 and TGFβR2 mRNA in non-cancer tissues in two expression groups, the TSP1 high- and low-expression groups, were examined. RESULTS: The expression of TSP1 was high in the mucosal-atrophy group and tended to be high in the Helicobacter pylori (H. pylori) (+) and multiple cancer groups. The levels of CD36, STAT3 and TGFβR2 mRNA were significantly higher in the TSP1-high group. TSP1 signaling pathway was induced in multiple cancer or atrophy (+) or H. pylori (+) compared to cases with single cancer, atrophy (-) and H. pylori (-). Expression of proteins involved in the TSP1 signaling pathway in non-cancer tissues with multiple gastric cancers were higher than that with single gastric cancer. CONCLUSION: Expression of TSP1 in non-cancer tissue correlated with gastric carcinogenesis. Copyright
BACKGROUND/AIM: Thrombospondin-1 (TSP1) is correlated with carcinogenesis occurring in cases of intestinal inflammation. The aim of this study was to clarify the role of TSP1 in gastric carcinogenesis. MATERIALS AND METHODS: A total of 39 patients with gastric cancer who had undergone gastrectomy were enrolled. The expression of TSP1 mRNA in non-cancer tissues was determined. Furthermore, the expression of CD36, STAT3 and TGFβR2 mRNA in non-cancer tissues in two expression groups, the TSP1 high- and low-expression groups, were examined. RESULTS: The expression of TSP1 was high in the mucosal-atrophy group and tended to be high in the Helicobacter pylori (H. pylori) (+) and multiple cancer groups. The levels of CD36, STAT3 and TGFβR2 mRNA were significantly higher in the TSP1-high group. TSP1 signaling pathway was induced in multiple cancer or atrophy (+) or H. pylori (+) compared to cases with single cancer, atrophy (-) and H. pylori (-). Expression of proteins involved in the TSP1 signaling pathway in non-cancer tissues with multiple gastric cancers were higher than that with single gastric cancer. CONCLUSION: Expression of TSP1 in non-cancer tissue correlated with gastric carcinogenesis. Copyright
Authors: Ana-Maria Enciu; Eugen Radu; Ionela Daniela Popescu; Mihail Eugen Hinescu; Laura Cristina Ceafalan Journal: Biomed Res Int Date: 2018-07-04 Impact factor: 3.411
Authors: Yu Young Joo; Jeong Won Jang; Sung Won Lee; Sun Hong Yoo; Jung Hyun Kwon; Soon Woo Nam; Si Hyun Bae; Jong Young Choi; Seung Kew Yoon Journal: Sci Rep Date: 2019-06-24 Impact factor: 4.379