Xiaowei Jiang1, Xu Dai1, Elliot Kale Edmiston2, Qian Zhou3, Ke Xu1, Yifang Zhou4, Feng Wu3, Lingtao Kong3, Shengnan Wei1, Yuning Zhou4, Miao Chang1, Haiyang Geng1, Dahai Wang5, Ye Wang5, Wenhui Cui5, Fei Wang6, Yanqing Tang7. 1. Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. 2. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. 3. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. 4. Department of Gerontology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. 5. Shenyang Mental Health Center, Shenyang, Liaoning, China. 6. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address: fei.wang@yale.edu. 7. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China; Department of Gerontology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address: yanqingtang@163.com.
Abstract
BACKGROUND: It is often difficult to differentiate major depressive disorder (MDD) and bipolar disorder (BD) merely according to clinical symptoms. Similarities and differences in neural activity between the two disorders remain unclear. In current study, we use amplitude of low-frequency fluctuations (ALFF) to compare neural activation changes between MDD and BD patients. METHODS: One hundred and eighty-three adolescents and young adults (57 MDD, 46 BD and 80 healthy controls, HC) were scanned during resting state. The ALFF for each participant was calculated, and were then compared among all groups using voxel-based analysis. RESULTS: There was a significant effect of diagnosis in the core regions of cortico-limbic-striatal neural system. Furthermore, MDD showed left-sided abnormal neural activity while BD showed a bilateral abnormality in this neural system. LIMITATIONS: This study was underpowered to consider medications, mood states and neural developmental effects on the neural activation. CONCLUSIONS: Differences in lateralization of ALFF alterations were found. Alterations predominated in the left hemisphere for MDD, whereas alterations were bilateral for BD.
BACKGROUND: It is often difficult to differentiate major depressive disorder (MDD) and bipolar disorder (BD) merely according to clinical symptoms. Similarities and differences in neural activity between the two disorders remain unclear. In current study, we use amplitude of low-frequency fluctuations (ALFF) to compare neural activation changes between MDD and BD patients. METHODS: One hundred and eighty-three adolescents and young adults (57 MDD, 46 BD and 80 healthy controls, HC) were scanned during resting state. The ALFF for each participant was calculated, and were then compared among all groups using voxel-based analysis. RESULTS: There was a significant effect of diagnosis in the core regions of cortico-limbic-striatal neural system. Furthermore, MDD showed left-sided abnormal neural activity while BD showed a bilateral abnormality in this neural system. LIMITATIONS: This study was underpowered to consider medications, mood states and neural developmental effects on the neural activation. CONCLUSIONS: Differences in lateralization of ALFF alterations were found. Alterations predominated in the left hemisphere for MDD, whereas alterations were bilateral for BD.