| Literature DB >> 28668380 |
H Azizi1, J Hwang1, V Suen1, N Z Kang1, R Somvanshi2, R Tadavarty1, U Kumar2, B R Sastry3.
Abstract
A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.Entities:
Keywords: 5-HT; CA1; EPSP; Hippocampus; Serotonin; Sleep deprivation
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Year: 2017 PMID： 28668380 DOI： 10.1016/j.neulet.2017.06.053
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046