| Literature DB >> 28668345 |
M Janaki Ramaiah1, Shaik Mohammad Naushad2, A Lavanya3, Chatla Srinivas3, Tangutur Anjana Devi3, Sowganthika Sampathkumar4, Dhepikha Bharani Dharan4, Manika Pal Bhadra5.
Abstract
Scriptaid (SCR), a well-known histone deacetylase inhibitor, cause various cellular effects such as cell growth inhibition and apoptosis. In this study, we have evaluated the anti-cancer effects of Scriptaid in HeLa cells, IMR-32 and HepG2 cells. Scriptaid inhibited the growth of HeLa cells with IC50 of 2μM at 48h in a dose-dependent manner. Flow-cytometric analysis indicated that SCR induced apoptosis. Scriptaid was found to inhibit HDAC-8 effectively than other HDAC inhibitor such as TSA as observed by HDAC-8 assay, Western blotting and modelling study. This observation was further strengthened by an artificial neuronal network (ANN) model.Entities:
Keywords: ANN; HDAC; HeLa; Scriptaid
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Year: 2017 PMID： 28668345 DOI： 10.1016/j.gene.2017.06.031
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688