[Intragastric acidity, serum gastrin and serum levels of the H2 receptor oxmetidine administered by continuous infusion].

The effect of 2-[2-(5-methyl-4-imidazolmethylthio)-ethyl-amino]-5-(3,4- methylendioxybenzyl)-4-pyrimidone dihydrochloride (oxmetidine) as continuous i.v. infusion over 11 1/2 h was tested with the doses of 12.5, 25 and 50 mg/h following an infusion of 200 mg over 30 min. In eight healthy male volunteers the parameters of gastric acid secretion were examined over 12 h as well as plasma oxmetidine and serum gastrin concentrations. Basal acid secretion was dose-dependently reduced from 53.1 mmol/12 h to minimally 3.2 mmol/12 h. A pH greater than or equal to 5 was reached for each volunteer under each dose, but even with the highest dose (50 mg/h) of oxmetidine a suppression of acid secretion up to the end of the 12-h experiment could not be observed.