Nobuhiro Yuki1,2, Amanda C Chan3, Anna Hiu Yi Wong1, Takayuki Inoue1, Masafumi Yokai4, Takashi Kurihara4, JérôMe J Devaux5, Einar Wilder-Smith1,3,6. 1. Department of Medicine, Yong Loo Lin School of Medicine, National University Singapore, 1E Kent Ridge Road, Singapore, 119228. 2. Department of Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore. 3. Department of Neurology, National University Hospital Systems, Singapore. 4. Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. 5. Aix-Marseille Université, CNRS, CRN2M-UMR 7286, Marseille, France. 6. Department of Neurology, Kantonsspital Luzern, Switzerland.
Abstract
INTRODUCTION: We present a painful small-fiber neuropathy variant of Guillain-Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. METHODS: Two patients received intravenous immunoglobulin, one corticosteroids. RESULTS: The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses. DISCUSSION: Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain-Barré syndrome. Muscle Nerve 57: 320-324, 2018.
INTRODUCTION: We present a painful small-fiber neuropathy variant of Guillain-Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. METHODS: Two patients received intravenous immunoglobulin, one corticosteroids. RESULTS: The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses. DISCUSSION: Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain-Barré syndrome. Muscle Nerve 57: 320-324, 2018.
Authors: N Strand; C Wie; J Peck; M Maita; N Singh; J Dumbroff; V Tieppo Francio; M Murphy; K Chang; D M Dickerson; J Maloney Journal: Curr Pain Headache Rep Date: 2022-04-06
Authors: Farinaz Safavi; Lindsey Gustafson; Brian Walitt; Tanya Lehky; Sara Dehbashi; Amanda Wiebold; Yair Mina; Susan Shin; Baohan Pan; Michael Polydefkis; Anne Louise Oaklander; Avindra Nath Journal: medRxiv Date: 2022-05-17
Authors: Francisco Antunes Dias; Ana Luiza Nunes Cunha; Patrícia Maria Pedrosa Pantoja; Carolina Lavigne Moreira; Pedro José Tomaselli; Maria Clara Zanon Zotin; Francisco Antônio Colleto; Soraia Ramos Cabette Fabio; Octavio M Pontes-Neto; Wilson Marques Júnior Journal: Neurol Clin Pract Date: 2021-04
Authors: Amanda C Y Chan; Hiu Yi Wong; Yao Feng Chong; Poh San Lai; Hock Luen Teoh; Alison Y Y Ng; Jennifer H M Hung; Yee Cheun Chan; Kay W P Ng; Joy Vijayan; Jonathan J Y Ong; Bharatendu Chandra; Chi Hsien Tan; Nurul H Rutt; Ti Myen Tan; Nur Hafiza Ismail; Einar Wilder-Smith; Herbert Schwarz; Hyungwon Choi; Vijay K Sharma; Anselm Mak Journal: Ann Neurol Date: 2021-12-01 Impact factor: 11.274