Literature DB >> 28667011

HLA-DP in unrelated hematopoietic cell transplantation revisited: challenges and opportunities.

Katharina Fleischhauer1,2, Bronwen E Shaw3.   

Abstract

When considering HLA-matched hematopoietic cell transplantation (HCT), sibling and unrelated donors (UDs) are biologically different because UD-HCT is typically performed across HLA-DP disparities absent in sibling HCT. Mismatched HLA-DP is targeted by direct alloreactive T cell responses with important implications for graft-versus-host disease and graft-versus-leukemia. This concise review details special features of HLA-DP as model antigens for clinically permissive mismatches mediating limited T-cell alloreactivity with minimal toxicity, and describes future avenues for their exploitation in cellular immunotherapy of malignant blood disorders.
© 2017 by The American Society of Hematology.

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Year:  2017        PMID： 28667011     DOI： 10.1182/blood-2017-03-742346

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  19 in total

1.  Learning the next-generation sequencing alphabet of immune reconstitution: factors determining CD8+ T-cell receptor α-chain repertoire dynamics after hematopoietic stem cell transplantation.

Authors:  Esteban Arrieta-Bolaños; Katharina Fleischhauer
Journal:  Haematologica       Date:  2019-03       Impact factor: 9.941

2.  Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation.

Authors:  Stéphane Buhler; Florence Bettens; Carole Dantin; Sylvie Ferrari-Lacraz; Marc Ansari; Anne-Claire Mamez; Stavroula Masouridi-Levrat; Yves Chalandon; Jean Villard
Journal:  Leukemia       Date:  2019-11-26       Impact factor: 11.528

3.  HLA-DPB1 mismatch reduce relapse and improve survival in T-cell replete unrelated donor allogeneic stem cell transplantation.

Authors:  Y Fløisand; T Gedde-Dahl; B Grønvold; M M Ali; M Remberger; J Mattsson; T Egeland; K U Lundin; A E Myhre; I W Abrahamsen; D Heldal; I Dybedal; G E Tjønnfjord
Journal:  Bone Marrow Transplant       Date:  2020-02-13       Impact factor: 5.483

4.  Clonal evolution and immune evasion in posttransplantation relapses.

Authors:  Luca Vago
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2019-12-06

5.  Molecular disparity in human leukocyte antigens is associated with outcomes in haploidentical stem cell transplantation.

Authors:  Jun Zou; Stefan O Ciurea; Piyanuch Kongtim; Min Yi; Yudith Carmazzi; Gabriela Rondon; Samer Srour; David Partlow; Richard E Champlin; Kai Cao
Journal:  Blood Adv       Date:  2020-08-11

6.  Selection of matched unrelated donors moving forward: from HLA allele counting to functional matching.

Authors:  Katharina Fleischhauer
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2019-12-06

7.  Development of an Unrelated Donor Selection Score Predictive of Survival after HCT: Donor Age Matters Most.

Authors:  Bronwen E Shaw; Brent R Logan; Stephen R Spellman; Steven G E Marsh; James Robinson; Joseph Pidala; Carolyn Hurley; Juliet Barker; Martin Maiers; Jason Dehn; Hailin Wang; Mike Haagenson; David Porter; Effie W Petersdorf; Ann Woolfrey; Mary M Horowitz; Michael Verneris; Katharine C Hsu; Katharina Fleischhauer; Stephanie J Lee
Journal:  Biol Blood Marrow Transplant       Date:  2018-02-14       Impact factor: 5.742

8.  Effect of nonpermissive HLA-DPB1 mismatches after unrelated allogeneic transplantation with in vivo T-cell depletion.

Authors:  Betül Oran; Rima M Saliba; Yudith Carmazzi; Marcos de Lima; Gabriela Rondon; Sairah Ahmed; Amin Alousi; Borje S Andersson; Paolo Anderlini; Michelle Alvarez; Qasier Bashir; Stefan Ciurea; Marcelo Fernandez-Vina; Chitra Hosing; Partow Kebriaei; Martin Korbling; Pedro Cano; Issa Khouri; David Marin; Yago Nieto; Amanda Olson; Uday Popat; Katy Rezvani; Muzaffar Qazilbash; Elizabeth J Shpall; Richard E Champlin; Kai Cao
Journal:  Blood       Date:  2018-01-31       Impact factor: 22.113

9.  In silico prediction of nonpermissive HLA-DPB1 mismatches in unrelated HCT by functional distance.

Authors:  Esteban Arrieta-Bolaños; Pietro Crivello; Bronwen E Shaw; Kwang Woo Ahn; Hai-Lin Wang; Michael R Verneris; Katharine C Hsu; Joseph Pidala; Stephanie J Lee; Katharina Fleischhauer; Stephen R Spellman
Journal:  Blood Adv       Date:  2018-07-24

10.  HLA-DPB1 Reactive T Cell Receptors for Adoptive Immunotherapy in Allogeneic Stem Cell Transplantation.

Authors:  Sebastian Klobuch; Kathrin Hammon; Sarah Vatter-Leising; Elisabeth Neidlinger; Michael Zwerger; Annika Wandel; Laura Maria Neuber; Bernhard Heilmeier; Regina Fichtner; Carina Mirbeth; Wolfgang Herr; Simone Thomas
Journal:  Cells       Date:  2020-05-20       Impact factor: 6.600
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