| Literature DB >> 28666737 |
Yoon Kyung Jang1, Kyu Myung Lee1, Kwan-Young Jung1, Seung Kyu Kang1, Suvarna H Pagire1, Jun Mi Lee1, Haushabhau S Pagire1, Kwang Rok Kim1, Myung Ae Bae1, Hohjai Lee2, Sang Dal Rhee1, Jin Hee Ahn3.
Abstract
A series of N-methoxyamide derivatives was identified and evaluated as GPR119 agonists. Several N-methoxyamides with thienopyrimidine and pyridine scaffolds showed potent GPR119 agonistic activities. Among them, compound 9c displayed good in vitro activity and potency. Moreover, compound 9c lowered glucose excursion in mice in an oral glucose tolerance test and increased GLP-1 secretion in intestinal cells.Entities:
Keywords: Diabetes; GPR119; N-methoxyamide derivative; Treatment
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Year: 2017 PMID： 28666737 DOI： 10.1016/j.bmcl.2017.06.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823