| Literature DB >> 28666370 |
Constance Delaugerre1,2, Guillemette Antoni3, Nadia Mahjoub1,2, Gilles Pialoux4, Eric Cua5, Armelle Pasquet6, Nolwenn Hall7, Cécile Tremblay8, Laurent Cotte9, Catherine Capitant3, Marie-Laure Chaix1,2,10, Laurence Meyer11,3, Jean-Michel Molina12,2.
Abstract
Preexposure prophylaxis programs involve frequent human immunodeficiency virus (HIV) testing. We evaluated the sensitivity of 2 antigen/antibody immunoassays (Architect and Bioplex), 2 antibody-based rapid tests (Vikia-HIV-1/2 and Autotest-VIH), and 1 antigen/antibody rapid test (Alere HIV Combo) for the diagnosis of HIV infection. Among the 31 HIV-1-infected participants in the ANRS-IPERGAY trial, HIV-1 RNA was detected alone in only 2. The sensitivities of the Architect and Bioplex assays were 83% (95% confidence interval [CI], 76%-99%) and 82% (95% CI, 63%-94%), respectively. The sensitivities of the Vikia, Autotest, and Alere tests were 54% (95% CI, 34%-72%), 50% (95% CI, 31%-69%), and 78% (95% CI, 58%-91%), respectively. Antigen/antibody tests should be preferred to avoid missing cases of acute HIV infection and to decrease the related risks of viral transmission and emergence of drug resistance.Entities:
Keywords: HIV diagnosis; HIV-1; HIV-1 RNA; PrEP; acute infection; antigen/antibody test; rapid test; recent infection
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Year: 2017 PMID： 28666370 DOI： 10.1093/infdis/jix297
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226