| Literature DB >> 28666326 |
Caroline Galeotti1,2,3,4, Srini V Kaveri1,2,3,5, Jagadeesh Bayry1,2,3,5.
Abstract
Intravenous immunoglobulin (IVIG) is a pooled preparation of normal IgG obtained from several thousand healthy donors. It is widely used in the immunotherapy of a large number of autoimmune and inflammatory diseases. The mechanisms of action of IVIG are complex and, as discussed in this review, experimental and clinical data provide an indicator that the therapeutic benefit of IVIG therapy is due to several mutually non-exclusive mechanisms affecting soluble mediators as well as cellular components of the immune system. These mechanisms depend on Fc and/or F(ab')2 fragments. A better understanding of the effector functions of IVIG should help in identification of biomarkers of responses to IVIG in autoimmune patients. © The Japanese Society for Immunology. 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.Entities:
Keywords: B cell; autoimmunity; dendritic cell; granulocyte; sialylation
Mesh：
Substances：
Year: 2017 PMID： 28666326 DOI： 10.1093/intimm/dxx039
Source DB: PubMed Journal: Int Immunol ISSN： 0953-8178 Impact factor: 4.823