Literature DB >> 28666114

A New Drug Target for Type 2 Diabetes.

Lukas K J Stadler1, I Sadaf Farooqi2.   

Abstract

Genetic studies can identify novel therapeutic targets for common complex diseases. In this issue of Cell, Rusu et al. demonstrate that a cluster of genetic variants associated with an increased risk of type 2 diabetes affect the function of a monocarboxylate transporter involved in nutrient flux and hepatic lipid metabolism.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28666114     DOI： 10.1016/j.cell.2017.06.024

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  6 in total

1.  Restoration of mRNA Expression of Solute Carrier Proteins in Liver of Diet-Induced Obese Mice by Metformin.

Authors:  Jiamei Le; Yi Fu; Qiuqin Han; Xindong Wei; Houlin Ji; Yifan Chen; Qiuying Wang; Peixian Pi; Jilei Li; Xinjie Lin; Xiaoying Zhang; Yong Zhang; Jianping Ye
Journal:  Front Endocrinol (Lausanne)       Date:  2021-09-30       Impact factor: 5.555

Review 2.  Precision medicine in diabetes: an opportunity for clinical translation.

Authors:  Jordi Merino; Jose C Florez
Journal:  Ann N Y Acad Sci       Date:  2018-01       Impact factor: 5.691

3.  STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia.

Authors:  Qinjie Weng; Mengting Zhao; Jiahuan Zheng; Lijun Yang; Zijie Xu; Zhikang Zhang; Jincheng Wang; Jiajia Wang; Bo Yang; Q Richard Lu; Meidan Ying; Qiaojun He
Journal:  Cell Death Differ       Date:  2019-05-16       Impact factor: 15.828

Review 4.  Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy.

Authors:  Pascale Fisel; Elke Schaeffeler; Matthias Schwab
Journal:  Clin Transl Sci       Date:  2018-04-16       Impact factor: 4.689

5.  Resveratrol metabolites ameliorate insulin resistance in HepG2 hepatocytes by modulating IRS-1/AMPK.

Authors:  Wendi Teng; Wenjing Yin; Liang Zhao; Changwei Ma; Jiaqiang Huang; Fazheng Ren
Journal:  RSC Adv       Date:  2018-10-23       Impact factor: 4.036

Review 6.  Significant Association between Microrna Gene Polymorphisms and Type 2 Diabetes Mellitus Susceptibility in Asian Population: A Meta-Analysis.

Authors:  Zhifang Deng; Wenqi Gao; Wei Luo; Li Ai; Min Hu
Journal:  Iran J Public Health       Date:  2020-05       Impact factor: 1.429
  6 in total

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