Silpa Dhoma Krefft1, Matthew Strand, Jennifer Smith, Catherine Stroup, Richard Meehan, Cecile Rose. 1. National Jewish Health Denver, Denver, Colorado (Dr Krefft, Dr Strand, Smith, Stroup, Dr Meehan, Dr Rose); VA Eastern Colorado Health Care System, Denver, Colorado (Dr Krefft); University of Colorado Anschutz Medical Campus, Aurora, Colorado (Drs Krefft, Strand, Rose); Colorado School of Public Health, Aurora, Colorado (Drs Krefft, Strand, Rose).
Abstract
OBJECTIVE: The aim of this study was to determine utility and sensitivity of lung clearance index (LCI) testing as a marker of lung injury in symptomatic military deployers compared with healthy controls. METHODS: We tested 24 healthy controls and 28 deployers with respiratory symptoms (17 of 28 with definite and 11 of 28 with probable deployment-related lung disease). We compared mean LCI scores between deployers and controls using t tests; adjusted tests were derived from multiple regression models. RESULTS: Mean LCI scores were significantly higher (P = 0.001) in deployers [7.76, 95% confidence interval (95% CI) 7.34 to 8.17] than controls (6.95, 95% CI 6.73 to 7.17). Adjusting for body mass index (BMI), smoking, and age, there were no significant differences (P = 0.10) between mean LCI scores in deployers (7.42, 95% CI 7.13 to 7.71) and controls (7.06, 95% CI 6.74 to 7.39). CONCLUSIONS: The trend toward higher LCI scores in symptomatic deployers may be linked to underlying lung disease and/or BMI but requires further investigation in a larger population.
OBJECTIVE: The aim of this study was to determine utility and sensitivity of lung clearance index (LCI) testing as a marker of lung injury in symptomatic military deployers compared with healthy controls. METHODS: We tested 24 healthy controls and 28 deployers with respiratory symptoms (17 of 28 with definite and 11 of 28 with probable deployment-related lung disease). We compared mean LCI scores between deployers and controls using t tests; adjusted tests were derived from multiple regression models. RESULTS: Mean LCI scores were significantly higher (P = 0.001) in deployers [7.76, 95% confidence interval (95% CI) 7.34 to 8.17] than controls (6.95, 95% CI 6.73 to 7.17). Adjusting for body mass index (BMI), smoking, and age, there were no significant differences (P = 0.10) between mean LCI scores in deployers (7.42, 95% CI 7.13 to 7.71) and controls (7.06, 95% CI 6.74 to 7.39). CONCLUSIONS: The trend toward higher LCI scores in symptomatic deployers may be linked to underlying lung disease and/or BMI but requires further investigation in a larger population.
Authors: Lauren M Zell-Baran; Silpa D Krefft; Camille M Moore; Jenna Wolff; Richard Meehan; Cecile S Rose Journal: Respir Med Date: 2020-12-05 Impact factor: 3.415
Authors: Eric Garshick; Joseph H Abraham; Coleen P Baird; Paul Ciminera; Gregory P Downey; Michael J Falvo; Jaime E Hart; David A Jackson; Michael Jerrett; Ware Kuschner; Drew A Helmer; Kirk D Jones; Silpa D Krefft; Timothy Mallon; Robert F Miller; Michael J Morris; Susan P Proctor; Carrie A Redlich; Cecile S Rose; Rudolph P Rull; Johannes Saers; Aaron I Schneiderman; Nicholas L Smith; Panayiotis Yiallouros; Paul D Blanc Journal: Ann Am Thorac Soc Date: 2019-08