Literature DB >> 2866490

Selection of sequence elements that substitute for the standard AATAAA motif which signals 3' processing and polyadenylation of late simian virus 40 mRNAs.

C Swimmer, T Shenk.   

Abstract

A method is described which allows selection of sequences which can substitute for the normal AATAAA hexanucleotide involved in polyadenylation of SV40 late mRNAs. Plaques were generated from viral DNA lacking the motif, forcing acquisition of substitute sequences. Four variants were characterized. All displayed wild-type growth kinetics and produced normal levels of late mRNAs and proteins. Two variants had reacquired AATAAA elements and one acquired an ATTAAA sequence. The last variant carried an ATTTTTTAAA segment, suggesting this novel sequence, or some portion of it, can also signal poly A addition.

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Year:  1985        PMID： 2866490      PMCID： PMC322109          DOI： 10.1093/nar/13.22.8053

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  48 in total

1.  A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.

Authors:  L Conway; M Wickens
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

2.  Mutants of simian virus 40 differing in plaque size, oncogenicity, and heat sensitivity.

Authors:  K K Takemoto; R L Kirschstein; K Habel
Journal:  J Bacteriol       Date:  1966-10       Impact factor: 3.490

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAs.

Authors:  M Fitzgerald; T Shenk
Journal:  Cell       Date:  1981-04       Impact factor: 41.582

5.  Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences.

Authors:  M Lusky; M Botchan
Journal:  Nature       Date:  1981-09-03       Impact factor: 49.962

6.  The primary transcription unit of the mouse beta-major globin gene.

Authors:  E Hofer; J E Darnell
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

7.  Multiple polyadenylation sites in a mouse alpha-amylase gene.

Authors:  M Tosi; R A Young; O Hagenbüchle; U Schibler
Journal:  Nucleic Acids Res       Date:  1981-05-25       Impact factor: 16.971

8.  DNA sequence required for efficient transcription termination in yeast.

Authors:  K S Zaret; F Sherman
Journal:  Cell       Date:  1982-03       Impact factor: 41.582

9.  Regulatory and coding potential of the mouse mammary tumor virus long terminal redundancy.

Authors:  L A Donehower; A L Huang; G L Hager
Journal:  J Virol       Date:  1981-01       Impact factor: 5.103

10.  The stability of early adenovirus mRNA is controlled by the viral 72 kd DNA-binding protein.

Authors:  A Babich; J R Nevins
Journal:  Cell       Date:  1981-11       Impact factor: 41.582
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  9 in total

1.  Deletions in the SV40 late polyadenylation region downstream of the AATAAA mediate similar effects on expression in various mammalian cell lines.

Authors:  E R Gimmi; K J Soprano; M Rosenberg; M E Reff
Journal:  Nucleic Acids Res       Date:  1988-09-26       Impact factor: 16.971

2.  Human dihydropteridine reductase: characterisation of a cDNA clone and its use in analysis of patients with dihydropteridine reductase deficiency.

Authors:  H H Dahl; W Hutchison; W McAdam; S Wake; F J Morgan; R G Cotton
Journal:  Nucleic Acids Res       Date:  1987-03-11       Impact factor: 16.971

3.  Tissue-specific expression of the human type II collagen gene in mice.

Authors:  R H Lovell-Badge; A Bygrave; A Bradley; E Robertson; R Tilly; K S Cheah
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

4.  Sequence homologies among the three yolk polypeptide (Yp) genes in Drosophila melanogaster.

Authors:  Y L Yan; C J Kunert; J H Postlethwait
Journal:  Nucleic Acids Res       Date:  1987-01-12       Impact factor: 16.971

5.  Honeybee blue- and ultraviolet-sensitive opsins: cloning, heterologous expression in Drosophila, and physiological characterization.

Authors:  S M Townson; B S Chang; E Salcedo; L V Chadwell; N E Pierce; S G Britt
Journal:  J Neurosci       Date:  1998-04-01       Impact factor: 6.167

6.  Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.

Authors:  B R Troen; S Gal; M M Gottesman
Journal:  Biochem J       Date:  1987-09-15       Impact factor: 3.857

7.  The mouse Col2a-1 gene is highly conserved and is linked to Int-1 on chromosome 15.

Authors:  K S Cheah; P K Au; E T Lau; P F Little; L Stubbs
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

8.  Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.

Authors:  K Mann; R Deutzmann; M Aumailley; R Timpl; L Raimondi; Y Yamada; T C Pan; D Conway; M L Chu
Journal:  EMBO J       Date:  1989-01       Impact factor: 11.598

9.  Mouse homologue of the human SART3 gene encoding tumor-rejection antigen.

Authors:  K Harada; A Yamada; T Mine; N Kawagoe; H Takasu; K Itoh
Journal:  Jpn J Cancer Res       Date:  2000-02
  9 in total

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