| Literature DB >> 28663680 |
Deepak Gunjan1, Neeti Nadda2, Saurabh Kedia2, Baibaswata Nayak2, Shashi B Paul3, Shivanand Ramachandra Gamanagatti3, Subrat K Acharya2.
Abstract
Wilson disease is caused by the accumulation of copper in the liver, brain or other organs, due to the mutation in ATP7B gene, which encodes protein that helps in excretion of copper in the bile canaliculus. Clinical presentation varies from asymptomatic elevation of transaminases to cirrhosis with decompensation. Hepatocellular carcinoma is a known complication of cirrhosis, but a rare occurrence in Wilson disease. We present a case of neurological Wilson disease, who later developed decompensated cirrhosis and hepatocellular carcinoma.Entities:
Keywords: ALP, alkaline phosphatise; ALT, alanine aminotransferase; ANA, anti-nuclear antibody; ASMA, anti-smooth muscle antibody; AST, aspartate aminotransferase; Barcelona clinic liver cancer (BCLC) staging; HCC, hepatocellular carcinoma; MPCT, multiphasic computed tomography; SAAG, serum-ascites albumin gradient; TACE, trans-arterial chemo-embolization; anti-LKM1, anti-liver kidney microsomal antibody type1; cirrhosis; d-penicillamine; decompensation
Year: 2016 PMID： 28663680 PMCID： PMC5478940 DOI： 10.1016/j.jceh.2016.09.012
Source DB: PubMed Journal: J Clin Exp Hepatol ISSN： 0973-6883