Literature DB >> 28663202

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study.

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Abstract

Entities:  

Year:  2017        PMID: 28663202      PMCID: PMC5490498          DOI: 10.1136/bmj.j3170

Source DB:  PubMed          Journal:  BMJ        ISSN: 0959-8138


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Two errors occurred in the print abstract of this paper (BMJ 2017;357:j1648, doi:10.1136/bmj.j1648). In both instances the level of low lipoprotein cholesterol was omitted. The study answers and limitations section should have stated that “Genetic evidence suggested that low low density lipoprotein cholesterol levels may lead to a low risk of Alzheimer’s dementia.” Similarly, the what this study adds section should have stated that “The findings suggest that low low density lipoprotein cholesterol has no harmful causal effect on risk of Alzheimer’s dementia, vascular dementia, any dementia, and Parkinson’s disease.”
  2 in total

1.  A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer.

Authors:  Aayah Nounu; Alexander Greenhough; Kate J Heesom; Rebecca C Richmond; Jie Zheng; Stephanie J Weinstein; Demetrius Albanes; John A Baron; John L Hopper; Jane C Figueiredo; Polly A Newcomb; Noralane M Lindor; Graham Casey; Elizabeth A Platz; Loïc Le Marchand; Cornelia M Ulrich; Christopher I Li; Fränzel J B van Duijnhoven; Andrea Gsur; Peter T Campbell; Víctor Moreno; Pavel Vodicka; Ludmila Vodickova; Hermann Brenner; Jenny Chang-Claude; Michael Hoffmeister; Lori C Sakoda; Martha L Slattery; Robert E Schoen; Marc J Gunter; Sergi Castellví-Bel; Hyeong Rok Kim; Sun-Seog Kweon; Andrew T Chan; Li Li; Wei Zheng; D Timothy Bishop; Daniel D Buchanan; Graham G Giles; Stephen B Gruber; Gad Rennert; Zsofia K Stadler; Tabitha A Harrison; Yi Lin; Temitope O Keku; Michael O Woods; Clemens Schafmayer; Bethany Van Guelpen; Steven Gallinger; Heather Hampel; Sonja I Berndt; Paul D P Pharoah; Annika Lindblom; Alicja Wolk; Anna H Wu; Emily White; Ulrike Peters; David A Drew; Dominique Scherer; Justo Lorenzo Bermejo; Ann C Williams; Caroline L Relton
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2020-12-14       Impact factor: 4.090

2.  Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.

Authors:  Susanna C Larsson; Matthew Traylor; Rainer Malik; Martin Dichgans; Stephen Burgess; Hugh S Markus
Journal:  BMJ       Date:  2017-12-06
  2 in total

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