Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Engineered Heart Repair.

Literature DB >> 28661033

Engineered Heart Repair.

Abstract

There is a pressing need for the development of advanced heart failure therapeutics. Current state-of-the-art is protection from neurohumoral overstimulation, which fails to address the underlying cause of heart failure, namely loss of cardiomyocytes. Implantation of stem cell-derived cardiomyocytes via tissue-engineered myocardium is being advanced to realize the remuscularization of the failing heart. Here, we discuss pharmacological challenges pertaining to the clinical translation of tissue-engineered heart repair with a focus on engineered heart muscle (EHM).

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Cardiovascular Agents

Year: 2017 PMID： 28661033 PMCID： PMC5657241 DOI： 10.1002/cpt.724

Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875

5 in total

1. Parthenogenetic stem cells for tissue-engineered heart repair.

Authors: Michael Didié; Peter Christalla; Michael Rubart; Vijayakumar Muppala; Stephan Döker; Bernhard Unsöld; Ali El-Armouche; Thomas Rau; Thomas Eschenhagen; Alexander P Schwoerer; Heimo Ehmke; Udo Schumacher; Sigrid Fuchs; Claudia Lange; Alexander Becker; Wen Tao; John A Scherschel; Mark H Soonpaa; Tao Yang; Qiong Lin; Martin Zenke; Dong-Wook Han; Hans R Schöler; Cornelia Rudolph; Doris Steinemann; Brigitte Schlegelberger; Steve Kattman; Alec Witty; Gordon Keller; Loren J Field; Wolfram-Hubertus Zimmermann
Journal: J Clin Invest Date: 2013-02-22 Impact factor: 14.808

2. Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model.

Authors: Johannes Riegler; Malte Tiburcy; Antje Ebert; Evangeline Tzatzalos; Uwe Raaz; Oscar J Abilez; Qi Shen; Nigel G Kooreman; Evgenios Neofytou; Vincent C Chen; Mouer Wang; Tim Meyer; Philip S Tsao; Andrew J Connolly; Larry A Couture; Joseph D Gold; Wolfram H Zimmermann; Joseph C Wu
Journal: Circ Res Date: 2015-08-19 Impact factor: 17.367

3. Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

Authors: Malte Tiburcy; James E Hudson; Paul Balfanz; Susanne Schlick; Tim Meyer; Mei-Ling Chang Liao; Elif Levent; Farah Raad; Sebastian Zeidler; Edgar Wingender; Johannes Riegler; Mouer Wang; Joseph D Gold; Izhak Kehat; Erich Wettwer; Ursula Ravens; Pieterjan Dierickx; Linda W van Laake; Marie Jose Goumans; Sara Khadjeh; Karl Toischer; Gerd Hasenfuss; Larry A Couture; Andreas Unger; Wolfgang A Linke; Toshiyuki Araki; Benjamin Neel; Gordon Keller; Lior Gepstein; Joseph C Wu; Wolfram-Hubertus Zimmermann
Journal: Circulation Date: 2017-02-06 Impact factor: 29.690

4. Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.

Authors: Wolfram-Hubertus Zimmermann; Ivan Melnychenko; Gerald Wasmeier; Michael Didié; Hiroshi Naito; Uwe Nixdorff; Andreas Hess; Lubos Budinsky; Kay Brune; Bjela Michaelis; Stefan Dhein; Alexander Schwoerer; Heimo Ehmke; Thomas Eschenhagen
Journal: Nat Med Date: 2006-04-02 Impact factor: 53.440

Review 5. Distilling complexity to advance cardiac tissue engineering.

Authors: Brenda M Ogle; Nenad Bursac; Ibrahim Domian; Ngan F Huang; Philippe Menasché; Charles E Murry; Beth Pruitt; Milica Radisic; Joseph C Wu; Sean M Wu; Jianyi Zhang; Wolfram-Hubertus Zimmermann; Gordana Vunjak-Novakovic
Journal: Sci Transl Med Date: 2016-06-08 Impact factor: 17.956

5 in total

3 in total

1. Process Improvement for Maximized Therapeutic Innovation Outcome.

Authors: Scott A Waldman; Andre Terzic
Journal: Clin Pharmacol Ther Date: 2018-01 Impact factor: 6.875

2. Health Care Evolves From Reactive to Proactive.

Authors: Scott A Waldman; Andre Terzic
Journal: Clin Pharmacol Ther Date: 2019-01 Impact factor: 6.875

3. Characteristics and toxicity assessment of electrospun gelatin/PCL nanofibrous scaffold loaded with graphene in vitro and in vivo.

Authors: Xi Chen; Bei Feng; Di-Qi Zhu; Yi-Wei Chen; Wei Ji; Tian-Ji Ji; Fen Li
Journal: Int J Nanomedicine Date: 2019-05-21

3 in total