Literature DB >> 2865965

Cloned neoplastic cells from a chemically-induced rat glioma: immunocytochemical characterization.

G J Pilkington, J M Martin, P L Lantos.   

Abstract

A cell clone--A15 A5--derived from an N-ethyl-N-nitrosourea (ENU)-induced glioma in a BDIX rat has been maintained in vitro for over 50 passages. These cells, which produce tumours when injected intracerebrally into syngeneic rats, possess several features of neoplastic astrocytes. In the present study A15 A5 cells were found to express both glial fibrillary acidic protein and glutamine synthetase, thus confirming their astrocytic nature.

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Year:  1985        PMID： 2865965      PMCID： PMC2042047     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  8 in total

1.  Mutually exclusive expression of fibronectin and glial fibrillary acidic protein in cultured brain cells.

Authors:  A Paetau; K Mellström; B Westermark; D Dahl; M Haltia; A Vaheri
Journal:  Exp Cell Res       Date:  1980-10       Impact factor: 3.905

2.  Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas.

Authors:  T R Jones; E Ruoslahti; S C Schold; D D Bigner
Journal:  Cancer Res       Date:  1982-01       Impact factor: 12.701

3.  Studies of the morphology and tumorigenicity of experimental brain tumours in tissue culture.

Authors:  P L Lantos; J P Roscoe; C J Skidmore
Journal:  Br J Exp Pathol       Date:  1976-02

4.  The role of glutamine synthetase in the diagnosis of cerebral tumours.

Authors:  G J Pilkington; P L Lantos
Journal:  Neuropathol Appl Neurobiol       Date:  1982 May-Jun       Impact factor: 8.090

5.  Cell lines (VMDk) derived from a spontaneous murine astrocytoma. Morphological and immunocytochemical characterization.

Authors:  G J Pilkington; J L Darling; P L Lantos; D G Thomas
Journal:  J Neurol Sci       Date:  1983-12       Impact factor: 3.181

6.  Isolation of intermediate filaments from rat astrocytes in culture.

Authors:  S Rasmussen; M Sensenbrenner; G Devilliers; A Schousboe; E Bock
Journal:  Neurosci Lett       Date:  1981-09-01       Impact factor: 3.046

Review 7.  High molecular weight, cell surface-associated glycoprotein (fibronectin) lost in malignant transformation.

Authors:  A Vaheri; D F Mosher
Journal:  Biochim Biophys Acta       Date:  1978-09-18

8.  A common cell-type specific surface antigen in cultured human glial cells and fibroblasts: loss in malignant cells.

Authors:  A Vaheri; E Ruoslahti; B Westermark; J Ponten
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307
  8 in total
  1 in total

1.  The effects of interferon on glial cells.

Authors:  M R Stratton; J M Martin; P L Lantos
Journal:  Br J Exp Pathol       Date:  1987-10
  1 in total

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